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The bone morphogene...
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
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Winbanks, Catherine E. (author)
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Chen, Justin L. (author)
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Qian, Hongwei (author)
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Liu, Yingying (author)
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Bernardo, Bianca C. (author)
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Beyer, Claudia (author)
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Watt, Kevin I. (author)
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Thomson, Rachel E. (author)
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Connor, Timothy (author)
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Turner, Bradley J. (author)
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McMullen, Julie R. (author)
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- Larsson, Lars (author)
- Uppsala universitet,Klinisk neurofysiologi
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McGee, Sean L. (author)
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Harrison, Craig A. (author)
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Gregorevic, Paul (author)
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(creator_code:org_t)
- 2013-10-21
- 2013
- English.
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In: Journal of Cell Biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 203:2, s. 345-357
- Related links:
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http://jcb.rupress.o...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Although the canonical transforming growth factor. signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report, for the first time, that the BMP pathway is a positive regulator of muscle mass. Increasing the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was dependent on Smad1/5-mediated activation of mTOR signaling. In agreement, we observed that BMP signaling is augmented in models of muscle growth. Importantly, stimulation of BMP signaling is essential for conservation of muscle mass after disruption of the neuromuscular junction. Inhibiting the phosphorylation of Smad1/5 exacerbated denervation-induced muscle atrophy via an HDAC4-myogenin-dependent process, whereas increased BMP-Smad1/5 activity protected muscles from denervation- induced wasting. Our studies highlight a novel role for the BMP signaling pathway in promoting muscle growth and inhibiting muscle wasting, which may have significant implications for the development of therapeutics for neuromuscular disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Winbanks, Cather ...
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Chen, Justin L.
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Qian, Hongwei
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Liu, Yingying
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Bernardo, Bianca ...
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Beyer, Claudia
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show more...
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Watt, Kevin I.
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Thomson, Rachel ...
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Connor, Timothy
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Turner, Bradley ...
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McMullen, Julie ...
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Larsson, Lars
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McGee, Sean L.
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Harrison, Craig ...
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Gregorevic, Paul
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Journal of Cell ...
- By the university
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Uppsala University