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Inflammatory biomar...
Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots, and weight loss
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- Witasp, Anna (author)
- Karolinska Institutet
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- Carrero, Juan Jesús (author)
- Karolinska Institutet
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi,Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
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- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi,Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
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- Kullberg, Joel (author)
- Uppsala universitet,Enheten för radiologi,Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
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- Adamsson, Viola (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Anestesiologi och intensivvård,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Helmersson-Karlqvist, Johanna (author)
- Uppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Stenvinkel, Peter (author)
- Karolinska Institutet
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden
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(creator_code:org_t)
- 2014-01-25
- 2014
- English.
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In: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 22:5, s. 1373-1379
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Abstract
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- OBJECTIVE: The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population.DESIGN AND METHODS: Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual-energy X-ray absorptiometry and magnetic resonance imaging, were assessed in three community-based cohorts: ULSAM, n = 790, mean age 78 years; PIVUS, n = 1003, mean age 70 years, women 50%; and the NORDIET-trial, n = 86, mean age 53 years, women 63%. Participants were re-examined after 5 years (PIVUS, n = 804) or following a 6-week randomized controlled dietary intervention (NORDIET).RESULTS: PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (P < 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (P < 0.001).CONCLUSIONS: These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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Obesity
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- By the author/editor
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Witasp, Anna
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Carrero, Juan Je ...
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Michaëlsson, Kar ...
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Ahlström, Håkan
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Kullberg, Joel
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Adamsson, Viola
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show more...
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Risérus, Ulf
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Larsson, Anders
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Helmersson-Karlq ...
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Lind, Lars
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Stenvinkel, Pete ...
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Ärnlöv, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Obesity
- By the university
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Uppsala University
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Högskolan Dalarna
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Karolinska Institutet