id:"swepub:oai:DiVA.org:uu-224347"
Sökning: id:"swepub:oai:DiVA.org:uu-224347" > The role of differe...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02945naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-224347 | |
| 003 | SwePub | |
| 008 | 140509s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2243472 URI |
| 024 | 7 | a https://doi.org/10.1038/ncb29262 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bentley, Katie4 aut |
| 245 | 1 0 | a The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis |
| 264 | c 2014-03-23 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2014 |
| 338 | a print2 rdacarrier | |
| 520 | a Endothelial cells show surprising cell rearrangement behaviour during angiogenic sprouting; however, the underlying mechanisms and functional importance remain unclear. By combining computational modelling with experimentation, we identify that Notch/VEGFR-regulated differential dynamics of VE-cadherin junctions drive functional endothelial cell rearrangements during sprouting. We propose that continual flux in Notch signalling levels in individual cells results in differential VE-cadherin turnover and junctional-cortex protrusions, which powers differential cell movement. In cultured endothelial cells, Notch signalling quantitatively reduced junctional VE-cadherin mobility. In simulations, only differential adhesion dynamics generated long-range position changes, required for tip cell competition and stalk cell intercalation. Simulation and quantitative image analysis on VE-cadherin junctional patterning in vivo identified that differential VE-cadherin mobility is lost under pathological high VEGF conditions, in retinopathy and tumour vessels. Our results provide a mechanistic concept for how cells rearrange during normal sprouting and how rearrangement switches to generate abnormal vessels in pathologies. | |
| 700 | 1 | a Franco, Claudio Areias4 aut |
| 700 | 1 | a Philippides, Andrew4 aut |
| 700 | 1 | a Blanco, Raquel4 aut |
| 700 | 1 | a Dierkes, Martina4 aut |
| 700 | 1 | a Gebala, Veronique4 aut |
| 700 | 1 | a Stanchi, Fabio4 aut |
| 700 | 1 | a Jones, Martin4 aut |
| 700 | 1 | a Aspalter, Irene M.4 aut |
| 700 | 1 | a Cagna, Guiseppe4 aut |
| 700 | 1 | a Weström, Simoneu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)simku408 |
| 700 | 1 | a Claesson-Welsh, Lenau Uppsala universitet,Cancer och vaskulärbiologi4 aut0 (Swepub:uu)lcl04207 |
| 700 | 1 | a Vestweber, Dietmar4 aut |
| 700 | 1 | a Gerhardt, Holger4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
| 773 | 0 | t Nature Cell Biologyd : Springer Science and Business Media LLCg 16:4, s. 309-321q 16:4<309-321x 1465-7392x 1476-4679 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224347 |
| 856 | 4 8 | u https://doi.org/10.1038/ncb2926 |
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