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FältnamnIndikatorerMetadata
00004559naa a2200529 4500
001oai:DiVA.org:uu-229708
003SwePub
008140812s2014 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e97dfbc7-e9ee-4f88-b6b6-b1bd2469f1b4
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2297082 URI
0247 a https://doi.org/10.1007/s11239-013-0987-82 DOI
0247 a https://lup.lub.lu.se/record/40657092 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wagner, Henriku Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hkw
2451 0a Higher body weight patients on clopidogrel maintenance therapy have lower active metabolite concentrations, lower levels of platelet inhibition, and higher rates of poor responders than low body weight patients
264 c 2013-09-17
264 1b Springer Science and Business Media LLC,c 2014
338 a print2 rdacarrier
520 a Body weight is a predictor of clopidogrel response. However, no prospective studies have compared pharmacodynamic (PD) and pharmacokinetic (PK) data based on body weight. We compared PD and PK effects of clopidogrel 75 mg in low body weight (LBW, <60 kg) and higher body weight (HBW, >= 60 kg) patients with stable coronary artery disease. LBW (n = 34, 56.4 +/- 3.7 kg) and HBW (n = 38, 84.7 +/- 14.9 kg) aspirin-treated patients received clopidogrel 75 mg for 10-14 days. The area under the concentration-time curve of active metabolite (Clop-AM) calculated through the last quantifiable concentration up to 4 h postdose, AUC((0-tlast)), was calculated by non-compartmental methods. Light transmission aggregometry (LTA) (maximum platelet aggregation and inhibition of platelet aggregation to 20 mu M adenosine diphosphate (ADP), and residual platelet aggregation to 5 mu M ADP), VerifyNow (R) P2Y12 reaction units (PRU), and vasodilator-associated stimulated phosphoprotein phosphorylation platelet reactivity index (VASP-PRI) were performed. Mean AUC((0-tlast)) was lower in HBW than LBW patients: 12.8 versus 17.9 ng h/mL. HBW patients had higher platelet reactivity as measured by LTA (all p <= 0.01), PRU (207 +/- 68 vs. 152 +/- 57, p < 0.001), and VASP-PRI (56 +/- 18 vs. 39 +/- 17, p < 0.001). More HBW patients exhibited high on-treatment platelet reactivity (HPR) using PRU (35 vs. 9 %) and VASP-PRI (65 vs. 27 %). Body weight correlated with PRU and VASP-PRI (both p < 0.001), and inversely with log transformed AUC((0-tlast)) (p < 0.001). In conclusion, HBW patients had lower levels of Clop-AM, and higher platelet reactivity and rates of HPR than LBW subjects, contributing to their suboptimal response to clopidogrel.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Body weight
653 a Clopidogrel
653 a Pharmacodynamics
653 a Pharmacokinetics
7001 a Angiolillo, Dominick J.4 aut
7001 a ten Berg, Jurrien M.4 aut
7001 a Bergmeijer, Thomas O.4 aut
7001 a Jakubowski, Joseph A.4 aut
7001 a Small, David S.4 aut
7001 a Moser, Brian A.4 aut
7001 a Zhou, Chunmei4 aut
7001 a Brown, Patricia4 aut
7001 a James, Stefanu Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Winters, Kenneth J.4 aut
7001 a Erlinge, Davidu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kard-der
7102 a Kardiologib Sektion II4 org
7730 t Journal of Thrombosis and Thrombolysisd : Springer Science and Business Media LLCg 38:2, s. 127-136q 38:2<127-136x 0929-5305x 1573-742X
8564 u http://www.ncbi.nlm.nih.gov/pubmed/24043374?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1007/s11239-013-0987-8y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229708
8564 8u https://doi.org/10.1007/s11239-013-0987-8
8564 8u https://lup.lub.lu.se/record/4065709

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