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Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer
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- Sandin, Linda C. (author)
- Uppsala universitet,Klinisk immunologi
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- Tötterman, Thomas H. (author)
- Uppsala universitet,Klinisk immunologi
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- Mangsbo, Sara M. (author)
- Uppsala universitet,Klinisk immunologi
- (creator_code:org_t)
- 2014-01
- 2014
- English.
- In: Oncoimmunology. - : Informa UK Limited. - 2162-4011 .- 2162-402X. ; 3:2
- Journal article (other academic/artistic)
Abstract
Subject headings
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- Local immunotherapy resurfaces in the field of cancer as a potential way to cure localized and metastatic disease with limited toxic effects. We have recently demonstrated that local administration of agonistic CD40 antibodies can cure localized as well as disseminated bladder neoplasms. This approach reduces the circulating concentrations of antibodies that would result from systemic delivery, hence resulting in limited toxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- antibody
- bladder cancer
- CD40
- local immunotherapy
Publication and Content Type
- vet (subject category)
- art (subject category)
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