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Cluster pattern ana...
Cluster pattern analysis of energy deposition sites for the brachytherapy sources 103Pd, 125I, 192Ir, 137Cs, and 60Co
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- Villegas, Fernanda, 1983- (författare)
- Uppsala universitet,Institutionen för radiologi, onkologi och strålningsvetenskap,Sjukhusfysik. Akademiska Sjukhuset, SE-75185 Uppsala, Sweden
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- Tilly, Nina (författare)
- Uppsala universitet,Institutionen för radiologi, onkologi och strålningsvetenskap,Elekta Instrument AB, Box 1704, 75147, Uppsala, Sweden
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- Gonzalez-Munoz, Gloria (författare)
- Uppsala universitet,Institutionen för radiologi, onkologi och strålningsvetenskap
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- Ahnesjö, Anders, 1953- (författare)
- Uppsala universitet,Institutionen för radiologi, onkologi och strålningsvetenskap
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(creator_code:org_t)
- 2014-08-29
- 2014
- Engelska.
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Ingår i: Physics in Medicine and Biology. - : Institute of Physics Publishing (IOPP). - 0031-9155 .- 1361-6560. ; 59:18, s. 5531-5543
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Analysing the pattern of energy depositions may help elucidate differences in the severity of radiation-induced DNA strand breakage for different radiation qualities. It is often claimed that energy deposition (ED) sites from photon radiation form a uniform random pattern, but there is indication of differences in RBE values among different photon sources used in brachytherapy. The aim of this work is to analyse the spatial patterns of EDs from 103Pd, 125I, 192Ir, 137Cs sources commonly used in brachytherapy and a 60Co source as a reference radiation. The results suggest that there is both a non-uniform and a uniform random component to the frequency distribution of distances to the nearest neighbour ED. The closest neighbouring EDs show high spatial correlation for all investigated radiation qualities, whilst the uniform random component dominates for neighbours with longer distances for the three higher mean photon energy sources (192Ir, 137Cs, and 60Co). The two lower energy photon emitters (103Pd and 125I) present a very small uniform random component. The ratio of frequencies of clusters with respect to 60Co differs up to 15% for the lower energy sources and less than 2% for the higher energy sources when the maximum distance between each pair of EDs is 2 nm. At distances relevant to DNA damage, cluster patterns can be differentiated between the lower and higher energy sources. This may be part of the explanation to the reported difference in RBE values with initial DSB yields as an endpoint for these brachytherapy sources.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- clusters
- energy deposition sites
- brachytherapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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