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In Vivo Quantificat...
In Vivo Quantification of Hypoxic and Metabolic Status of NSCLC Tumors Using [18F]HX4 and [18F]FDG-PET/CT Imaging.
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- Zegers, Catharina M L (author)
- Maastricht University Medical Centre
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- van Elmpt, Wouter (author)
- Maastricht University Medical Centre
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- Reymen, Bart (author)
- Maastricht University Medical Centre
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- Even, Aniek J G (author)
- Maastricht University Medical Centre
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- Troost, Esther G C (author)
- Maastricht University Medical Centre
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- Ollers, Michel C (author)
- Maastricht University Medical Centre
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- Hoebers, Frank J P (author)
- Maastricht University Medical Centre
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- Houben, Ruud M A (author)
- Maastricht University Medical Centre
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- Eriksson, Jonas (author)
- VU University Medical Centre, Amsterdam
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- Windhorst, Albert D (author)
- VU University Medical Centre, Amsterdam
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- Mottaghy, Felix M (author)
- Maastricht University Medical Centre
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- De Ruysscher, Dirk (author)
- Maastricht University Medical Centre
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- Lambin, Philippe (author)
- Maastricht University Medical Centre
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Clinical cancer research. - 1078-0432. ; 20:24, s. 6389-6397
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Increased tumor metabolism and hypoxia are related to poor prognosis in solid tumors, including non-small cell lung cancer (NSCLC). PET imaging is a noninvasive technique that is frequently used to visualize and quantify tumor metabolism and hypoxia. The aim of this study was to perform an extensive comparison of tumor metabolism using 2[(18)F]fluoro-2-deoxy-d-glucose (FDG)-PET and hypoxia using HX4-PET imaging.EXPERIMENTAL DESIGN: FDG- and HX4-PET/CT images of 25 patients with NSCLC were coregistered. At a global tumor level, HX4 and FDG parameters were extracted from the gross tumor volume (GTV). The HX4 high-fraction (HX4-HF) and HX4 high-volume (HX4-HV) were defined using a tumor-to-blood ratio > 1.4. For FDG high-fraction (FDG-HF) and FDG high-volume (FDG-HV), a standardized uptake value (SUV) > 50% of SUVmax was used. We evaluated the spatial correlation between HX4 and FDG uptake within the tumor, to quantify the (mis)match between volumes with a high FDG and high HX4 uptake.RESULTS: At a tumor level, significant correlations were observed between FDG and HX4 parameters. For the primary GTV, the HX4-HF was three times smaller compared with the FDG-HF. In 53% of the primary lesions, less than 1 cm(3) of the HX4-HV was outside the FDG-HV; for 37%, this volume was 1.9 to 12 cm(3). Remarkably, a distinct uptake pattern was observed in 11%, with large hypoxic volumes localized outside the FDG-HV.CONCLUSION: Hypoxic tumor volumes are smaller than metabolic active volumes. Approximately half of the lesions showed a good spatial correlation between the PET tracers. In the other cases, a (partial) mismatch was observed. The addition of HX4-PET imaging has the potential to individualize patient treatment. Clin Cancer Res; 1-9. ©2014 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Zegers, Catharin ...
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van Elmpt, Woute ...
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Reymen, Bart
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Even, Aniek J G
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Troost, Esther G ...
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Ollers, Michel C
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show more...
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Hoebers, Frank J ...
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Houben, Ruud M A
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Eriksson, Jonas
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Windhorst, Alber ...
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Mottaghy, Felix ...
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De Ruysscher, Di ...
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Lambin, Philippe
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Clinical cancer ...
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Uppsala University