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Increased Risk of A...
Increased Risk of All-Cause Mortality and Renal Graft Loss in Stable Renal Transplant Recipients With Hyperparathyroidism
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Pihlstrom, Hege (author)
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Dahle, Dag Olav (author)
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Mjoen, Geir (author)
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Pilz, Stefan (author)
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Maerz, Winfried (author)
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Abedini, Sadollah (author)
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Holme, Ingar (author)
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- Fellström, Bengt (author)
- Uppsala universitet,Njurmedicin
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Jardine, Alan G. (author)
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Holdaas, Hallvard (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Transplantation. - 0041-1337 .- 1534-6080. ; 99:2, s. 351-359
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background. Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. Methods. We investigated the association between baseline parathyroid hormone (PTH) levels and major cardiovascular events, renal graft loss, and all-cause mortality by Cox Proportional Hazard survival analyses in 1840 stable RTR derived from the Assessment of LEscol in Renal Transplantation trial. Patients were recruited in a mean of 5.1 years after transplantation, and follow-up time was 6 to 7 years. Results. Significant associations between PTH and all 3 outcomes were found in univariate analyses. When adjusting for a range of plausible confounders, including measures of renal function and serum mineral levels, PTH remained significantly associated with all-cause mortality (4% increased risk per 10 units; P = 0.004), and with graft loss (6% increased risk per 10 units; P < 0.001), but not with major cardiovascular events. Parathyroid hormone above the upper limit of normal (65 pg/mL) indicated a 46% (P = 0.006) higher risk of death and an 85% higher risk of graft loss (P < 0.001) compared with low/normal values. Conclusions. Hyperparathyroidismis an independent, potentially remediable, risk factor for renal graft loss and all-cause mortality in RTR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Pihlstrom, Hege
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Dahle, Dag Olav
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Mjoen, Geir
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Pilz, Stefan
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Maerz, Winfried
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Abedini, Sadolla ...
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show more...
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Holme, Ingar
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Fellström, Bengt
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Jardine, Alan G.
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Holdaas, Hallvar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Transplantation
- By the university
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Uppsala University