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Cell types in the m...
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
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- Zeisel, Amit (author)
- Karolinska Institutet
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- Munoz-Manchado, Ana B. (author)
- Karolinska Institutet
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- Codeluppi, Simone (author)
- Karolinska Institutet
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- Lonnerberg, Peter (author)
- Karolinska Institutet
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- La Manno, Gioele (author)
- Karolinska Institutet
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- Jureus, Anna (author)
- Karolinska Institutet
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- Marques, Sueli (author)
- Karolinska Institutet
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- Munguba, Hermany (author)
- Karolinska Institutet
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- He, Liqun (author)
- Uppsala universitet,Vaskulärbiologi
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- Betsholtz, Christer (author)
- Karolinska Institutet,Uppsala universitet,Vaskulärbiologi
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- Rolny, Charlotte (author)
- Karolinska Institutet
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- Castelo-Branco, Goncalo (author)
- Karolinska Institutet
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- Hjerling-Leffler, Jens (author)
- Karolinska Institutet
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- Linnarsson, Sten (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2015
- 2015
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6226, s. 1138-1142
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature. Here, we have used large-scale single-cell RNA sequencing (RNA-seq) to classify cells in the mouse somatosensory cortex and hippocampal CA1 region. We found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex. We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. We found a layer I interneuron expressing Pax6 and a distinct postmitotic oligodendrocyte subclass marked by Itpr2. Across the diversity of cortical cell types, transcription factors formed a complex, layered regulatory code, suggesting a mechanism for the maintenance of adult cell type identity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zeisel, Amit
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Munoz-Manchado, ...
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Codeluppi, Simon ...
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Lonnerberg, Pete ...
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La Manno, Gioele
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Jureus, Anna
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show more...
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Marques, Sueli
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Munguba, Hermany
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He, Liqun
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Betsholtz, Chris ...
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Rolny, Charlotte
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Castelo-Branco, ...
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Hjerling-Leffler ...
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Linnarsson, Sten
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Science
- By the university
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Uppsala University
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Karolinska Institutet