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Randomized study on...
Randomized study on simple versus complex stenting of coronary artery bifurcation lesions : the Nordic bifurcation study
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Steigen, Terje K. (author)
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Maeng, Michael (author)
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Wiseth, Rune (author)
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Erglis, Andrejs (author)
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Kumsars, Indulis (author)
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Narbute, Inga (author)
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Gunnes, Pål (author)
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Mannsverk, Jan (author)
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Meyerdierks, Oliver (author)
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Rotevatn, Svein (author)
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Niemelä, Matti (author)
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Kervinen, Kari (author)
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Jensen, Jan S. (author)
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Gallöe, Anders (author)
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Nikus, Kjell (author)
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Vikman, Saila (author)
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Ravkilde, Jan (author)
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- James, Stefan, 1964- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
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Aaröe, Jens (author)
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Ylitalo, Antti (author)
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Helqvist, Steffen (author)
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Sjögren, Iwar (author)
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Thayssen, Per (author)
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Virtanen, Kari (author)
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Puhakka, Mikko (author)
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Airaksinen, Juhani (author)
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Lassen, Jens F. (author)
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Thuesen, Leif (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Circulation. - 0009-7322 .- 1524-4539. ; 114:18, s. 1955-1961
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background - The optimal stenting strategy in coronary artery bifurcation lesions is unknown. In the present study, a strategy of stenting both the main vessel and the side branch ( MV + SB) was compared with a strategy of stenting the main vessel only, with optional stenting of the side branch ( MV), with sirolimus-eluting stents. Methods and Results - A total of 413 patients with a bifurcation lesion were randomized. The primary end point was a major adverse cardiac event: cardiac death, myocardial infarction, target-vessel revascularization, or stent thrombosis after 6 months. At 6 months, there were no significant differences in rates of major adverse cardiac events between the groups ( MV + SB 3.4%, MV 2.9%; P = NS). In the MV + SB group, there were significantly longer procedure and fluoroscopy times, higher contrast volumes, and higher rates of procedure-related increases in biomarkers of myocardial injury. A total of 307 patients had a quantitative coronary assessment at the index procedure and after 8 months. The combined angiographic end point of diameter stenosis > 50% of main vessel and occlusion of the side branch after 8 months was found in 5.3% in the MV group and 5.1% in the MV + SB group ( P = NS). Conclusions - Independent of stenting strategy, excellent clinical and angiographic results were obtained with percutaneous treatment of de novo coronary artery bifurcation lesions with sirolimus-eluting stents. The simple stenting strategy used in the MV group was associated with reduced procedure and fluoroscopy times and lower rates of procedure-related biomarker elevation. Therefore, this strategy can be recommended as the routine bifurcation stenting technique.
Keyword
- stents
- angioplasty
- angiography
- restenosis
- bifurcation
- follow-up studies
- stenosis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Steigen, Terje K ...
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Maeng, Michael
-
Wiseth, Rune
-
Erglis, Andrejs
-
Kumsars, Indulis
-
Narbute, Inga
-
show more...
-
Gunnes, Pål
-
Mannsverk, Jan
-
Meyerdierks, Oli ...
-
Rotevatn, Svein
-
Niemelä, Matti
-
Kervinen, Kari
-
Jensen, Jan S.
-
Gallöe, Anders
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Nikus, Kjell
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Vikman, Saila
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Ravkilde, Jan
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James, Stefan, 1 ...
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Aaröe, Jens
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Ylitalo, Antti
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Helqvist, Steffe ...
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Sjögren, Iwar
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Thayssen, Per
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Virtanen, Kari
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Puhakka, Mikko
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Airaksinen, Juha ...
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Lassen, Jens F.
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Thuesen, Leif
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show less...
- Articles in the publication
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Circulation
- By the university
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Uppsala University