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Disorganised stroma...
Disorganised stroma determined on pre-treatment breast cancer biopsies is associated with poor response to neoadjuvant chemotherapy : Results from the NEOZOTAC trial
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Dekker, T. J. A. (author)
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Charehbili, A. (author)
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Smit, V. T. H. B. M. (author)
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- ten Dijke, Peter (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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Kranenbarg, E. Meershoek-Klein (author)
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van de Velde, C. J. H. (author)
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Nortier, J. W. R. (author)
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Tollenaar, R. A. E. M. (author)
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Mesker, W. E. (author)
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Kroep, J. R. t f (author)
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(creator_code:org_t)
- 2015-02-14
- 2015
- English.
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In: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 9:6, s. 1120-1128
- Related links:
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https://febs.onlinel...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: The tumor-associated stoma is of importance for tumor progression and is generally accepted to have a significant influence on patient prognosis. However, little is known regarding specific features of tumor-associated stromal tissues and response to (neoadjuvant) chemotherapy. This study investigated the predictive value of extracellular matrix organization on response to chemotherapy in patients treated in the NEOZOTAC trial. Methods: Stromal organisation was analyzed via a simple method using image analysis software on hematoxylin and eosin (H&E)-stained slides from primary tumor biopsies collected as part of the NEOZOTAC trial. Heidenhain's AZAN trichrome-stained slides were also analyzed for comparison of collagen evaluation. Sections were stained for phospho-Smad2 (pS2) in order to determine the relationship of TGF-beta signaling with stromal organization. Results: A statistically significant relationship was observed between stroma consisting of organised collagen and pathological response to neoadjuvant chemotherapy (Odds Ratio 0.276, 95%CI 0.124-0.614, P = 0.002). This parameter was also related to ER-status (P = 0.003), clinical tumor -status (P = 0.041), nodal status (P = 0.029) and pS2 status (P = 0.025). Correlation between stromal organisation determined on H&E-stained and AZAN-stained tissue sections was high (Pearson's correlation coefficient = 0.806). Conclusion: Intratumoral stromal organisation determined using pre-treatment breast cancer biopsies was related to pathological response to chemotherapy. This parameter might play a role in the management of breast cancer for identifying those patients that are likely to benefit from neoadjuvant chemotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Stoma
- Breast cancer
- Organisation
- TGF-B
- Neoadjuvant
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dekker, T. J. A.
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Charehbili, A.
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Smit, V. T. H. B ...
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ten Dijke, Peter
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Kranenbarg, E. M ...
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van de Velde, C. ...
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show more...
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Nortier, J. W. R ...
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Tollenaar, R. A. ...
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Mesker, W. E.
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Kroep, J. R. t f
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Molecular Oncolo ...
- By the university
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Uppsala University