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Disorganised stroma determined on pre-treatment breast cancer biopsies is associated with poor response to neoadjuvant chemotherapy : Results from the NEOZOTAC trial
- Dekker, T. J. A. (author)
- Charehbili, A. (author)
- Smit, V. T. H. B. M. (author)
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- Kranenbarg, E. Meershoek-Klein (author)
- van de Velde, C. J. H. (author)
- Nortier, J. W. R. (author)
- Tollenaar, R. A. E. M. (author)
- Mesker, W. E. (author)
- Kroep, J. R. t f (author)
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- (creator_code:org_t)
- 2015-02-14
- 2015
- English.
- In: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 9:6, s. 1120-1128
- Journal article (peer-reviewed)
Abstract
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- Introduction: The tumor-associated stoma is of importance for tumor progression and is generally accepted to have a significant influence on patient prognosis. However, little is known regarding specific features of tumor-associated stromal tissues and response to (neoadjuvant) chemotherapy. This study investigated the predictive value of extracellular matrix organization on response to chemotherapy in patients treated in the NEOZOTAC trial. Methods: Stromal organisation was analyzed via a simple method using image analysis software on hematoxylin and eosin (H&E)-stained slides from primary tumor biopsies collected as part of the NEOZOTAC trial. Heidenhain's AZAN trichrome-stained slides were also analyzed for comparison of collagen evaluation. Sections were stained for phospho-Smad2 (pS2) in order to determine the relationship of TGF-beta signaling with stromal organization. Results: A statistically significant relationship was observed between stroma consisting of organised collagen and pathological response to neoadjuvant chemotherapy (Odds Ratio 0.276, 95%CI 0.124-0.614, P = 0.002). This parameter was also related to ER-status (P = 0.003), clinical tumor -status (P = 0.041), nodal status (P = 0.029) and pS2 status (P = 0.025). Correlation between stromal organisation determined on H&E-stained and AZAN-stained tissue sections was high (Pearson's correlation coefficient = 0.806). Conclusion: Intratumoral stromal organisation determined using pre-treatment breast cancer biopsies was related to pathological response to chemotherapy. This parameter might play a role in the management of breast cancer for identifying those patients that are likely to benefit from neoadjuvant chemotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Stoma
- Breast cancer
- Organisation
- TGF-B
- Neoadjuvant
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- van de Velde, C. ...
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- Nortier, J. W. R ...
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- Mesker, W. E.
- Kroep, J. R. t f
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