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Effect of genetic a...
Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)
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- Enroth, Stefan (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Enroth, Sofia Bosdotter (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Johansson, Åsa (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Gyllensten, Ulf (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Biomarkers. - 1354-750X .- 1366-5804. ; 20:6-7, s. 355-364
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.Materials and methods: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.Results: Genetic and lifestyle factors explained 20-88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.Conclusion: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Non-communicable diseases
- normalization
- plasma protein biomarkers
- proximity extension assay
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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