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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004553naa a2200469 4500
001oai:DiVA.org:uu-275881
003SwePub
008160208s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132742971
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2758812 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1327429712 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Martensson, J.u Karolinska Institutet4 aut
2451 0a Urinary neutrophil gelatinase-associated lipocalin to hepcidin ratio as a biomarker of acute kidney injury in intensive care unit patients
264 1c 2015
338 a print2 rdacarrier
520 a Background. Labile iron is important in the pathogenesis of acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress. However, higher levels of urinary NGAL are associated with AKI severity whereas higher urinary hepcidin levels are associated with absence of AKI. We aimed to investigate the value of combining both biomarkers to estimate the severity and progression of AKI in intensive care unit (ICU) patients. Methods. Urinary NGAL and hepcidin were quantified within 48 hours of ICU admission in patients with the systemic inflammatory response syndrome and early kidney dysfunction (oliguria for >= 2 hours and/or a 25 mu mol/L creatinine rise from baseline). Diagnostic and prognostic characteristics were assessed by logistic regression and receiver operating characteristics (ROC) analysis. Results. Of 102 patients, 26 had mild AKI and 28 patients had severe AKI on admission. Sepsis (21%), cardiac surgery (17%) and liver failure (9%) were primary admission diagnoses. NGAL increased (P=0.03) whereas hepcidin decreased (P=0.01) with increasing AKI severity. The value of NGAL/hepcidin ratio to detect severe AKI was higher than when NGAL and hepcidin were used individually and persisted after adjusting for potential confounders (adjusted OR 2.40, 95% CI 1.20-4.78). The ROC areas for predicting worsening AKI were 0.50, 0.52 and 0.48 for NGAL, 1/hepcidin and the NGAL/hepcidin ratio. Conclusion. The NGAL/hepcidin ratio is more strongly associated with severe AKI than the single biomarkers alone. NGAL and hepcidin, alone or combined as a ratio, were unable to predict progressive AKI in this selected ICU cohort.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a LCN2 protein
653 a human
653 a Hepcidins
653 a Acute Kidney Injury
653 a Oliguria
653 a Iron
7001 a Glassford, N. J.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Monash Univ, Sch Prevent Med & Publ Hlth, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia.4 aut
7001 a Jones, S.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.4 aut
7001 a Eastwood, G. M.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Deakin Univ, Sch Nursing & Midwifery, Melbourne, Vic 3004, Australia.4 aut
7001 a Young, H.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.4 aut
7001 a Peck, L.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.4 aut
7001 a Ostland, V.u Intrins LifeSci LLC, La Jolla, CA USA.4 aut
7001 a Westerman, M.u Intrins LifeSci LLC, La Jolla, CA USA.4 aut
7001 a Venge, Peru Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)pervenge
7001 a Bellomo, R.u Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Monash Univ, Sch Prevent Med & Publ Hlth, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia.4 aut
7102 a Karolinska Institutetb Austin Hosp, Dept Intens Care, Melbourne, Vic 3084, Australia.;Monash Univ, Sch Prevent Med & Publ Hlth, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia.4 org
7730 t Minerva Anestesiologicag 81:11, s. 1192-1200q 81:11<1192-1200x 0375-9393x 1827-1596
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275881
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132742971

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