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Definition of noctu...
Definition of nocturnal gastroesophageal reflux for studies on respiratory diseases
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- Emilsson, Össur Ingi (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
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- Benediktsdottir, Bryndis (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
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- Olafsson, Isleifur (författare)
- Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
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- Cook, Elizabeth (författare)
- Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
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- Juliusson, Sigurdur (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Ear Nose & Throat, Reykjavik, Iceland.
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- Berg, Sören (författare)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Otolaryngol & Head & Neck Surg, Lund, Sweden.
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- Nordang, Leif (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Björnsson, Einar Stefan (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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- Gudlaugsdottir, Sunna (författare)
- Landspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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- Gudmundsdottir, Anna Soffia (författare)
- Landspitali Univ Hosp, Dept Gastroenterol, Reykjavik, Iceland.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Gislason, Thorarinn (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland.
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(creator_code:org_t)
- 2016-01-29
- 2016
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 51:5, s. 524-530
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective Nocturnal gastroesophageal reflux (nGER) has been associated with respiratory diseases. Our aim was to study a questionnaire method to identify nGER subjects with respiratory involvement in a general population. Material and methods A subgroup of Icelandic participants in the European Community Respiratory Health Survey III (ECRHS III) reporting symptoms of nGER (n =48) as well as age and gender paired controls (n =42) were studied further by a structured interview, questionnaires, laryngeal fibrescopy, and exhaled breath condensate. A subgroup underwent 24-h oesophageal pH impedance (24-h MII-pH) measurements. Symptoms of nGER were assessed with a modified version of the reflux disease questionnaire (RDQ), where symptoms were divided into daytime and nocturnal. A report of nGER both at baseline and at follow-up was defined as persistent nGER. Results Participants reporting persistent nGER had significantly more signs of laryngopharyngeal reflux according to the reflux finding score than those without nGER (Mean +/- SD: 5.1 +/- 2.3 vs. 3.9 +/- 2.2, p =0.02). Of the 16 persistent nGER subjects that underwent 24-h MII-pH, 11 had abnormal gastroesophageal reflux, but none of three control subjects (69% vs. 0%). Pepsin was more commonly found in exhaled breath condensate in the nGER group (67% vs. 45%, p =0.04). Conclusions Participants with nGER symptoms at least once a month, reported on two occasions, had a high level of positive 24-h MII-pH measurements, laryngeal inflammation and pepsin in exhaled breath condensate. This nGER definition identified a representable group for studies on nGER and respiratory diseases in a general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Asthma
- laryngopharyngeal reflux
- nocturnal gastroesophageal reflux
- pepsin
- reflux disease questionnaire
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Emilsson, Össur ...
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Benediktsdottir, ...
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Olafsson, Isleif ...
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Cook, Elizabeth
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Juliusson, Sigur ...
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Berg, Sören
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Nordang, Leif
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Björnsson, Einar ...
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Gudlaugsdottir, ...
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Gudmundsdottir, ...
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Janson, Christer
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Gislason, Thorar ...
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