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Urgent surgery or p...
Urgent surgery or procedures in patients taking dabigatran or warfarin : Analysis of perioperative outcomes from the RE-LY trial
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- Douketis, James D. (author)
- McMaster Univ, Dept Med, Hamilton, ON, Canada.
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- Healey, Jeff S. (author)
- McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Brueckmann, Martina (author)
- Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.;Mannheim Univ Heidelberg, Fac Med, Heidelberg, Germany.
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- Fraessdorf, Mandy (author)
- Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.
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- Spyropoulos, Alex C. (author)
- Hofstra North Shore Long Isl Jewish Sch Med, Manhasset, NY USA.
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Oldgren, Jonas (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Reilly, Paul (author)
- Boehringer Ingelheim Pharmaceut, Ridgefield, CT USA.
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- Ezekowitz, Michael D. (author)
- Jefferson Med Coll, Wynnewood, PA USA.
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- Connolly, Stuart J. (author)
- McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Yusuf, Salim (author)
- McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Eikelboom, John W. (author)
- McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
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McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 139, s. 77-81
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: There is concern about the management of anticoagulated patients with atrial fibrillation (AF) who require an urgent surgery/procedure, especially in those who are receiving a direct oral anticoagulant such as dabigatran. Methods: We accessed the database from RE-LY, a randomized trial comparing dabigatran (110 mg and 150 mg twice daily) with warfarin for stroke prevention in AF, to assess patients who had an urgent and elective surgery/procedure. We compared the risk for thromboembolism, major bleeding and mortality according to treatment allocation (dabigatran 110 mg or 150 mg, or warfarin) or surgery/procedure type (urgent or elective). Outcomes were assessed from day-7 to day 30 after a surgery/procedure. Results: 353 patients (2.0% of study population) had an urgent surgery/procedure and 4168 patients (23.1% of study population) had an elective surgery/procedure. In patients on dabigatran 110 mg, dabigatran 150 mg and warfarin who had an urgent surgery/procedure: rates of thromboembolism were 16.1%, 7.4%, and 10.5%; rates of major bleeding were 17.0%, 17.6%, and 22.9%; rates of mortality were 6.3%, 1.5%, and 2.9%, respectively (P > 0.50 for all comparisons). Rates of these outcomes were multi-fold higher in patients having an urgent rather than an elective surgery/procedure (P < 0.5 for all comparisons). Conclusion: In anticoagulated patients with atrial fibrillation who require an urgent surgery/procedure, the risks for thromboembolism, major bleeding and mortality did not differ depending on treatment with dabigatran or warfarin, but rates of these outcomes were multi-fold higher than in patients having an elective surgery/procedure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Urgent surgery
- Dabigatran
- Warfarin
- Perioperative
Publication and Content Type
- ref (subject category)
- for (subject category)
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Douketis, James ...
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Healey, Jeff S.
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Brueckmann, Mart ...
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Fraessdorf, Mand ...
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Spyropoulos, Ale ...
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Wallentin, Lars
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Oldgren, Jonas
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Reilly, Paul
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Ezekowitz, Micha ...
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Connolly, Stuart ...
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Yusuf, Salim
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Eikelboom, John ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Thrombosis Resea ...
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Uppsala University