id:"swepub:oai:DiVA.org:uu-298144"
Sökning: id:"swepub:oai:DiVA.org:uu-298144" > Genetic Regulation ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05043naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-298144 | |
| 003 | SwePub | |
| 008 | 160630s2016 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:134119105 | |
| 009 | oai:slubar.slu.se:83221 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2981442 URI |
| 024 | 7 | a https://doi.org/10.1534/g3.116.0308742 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1341191052 URI |
| 024 | 7 | a https://res.slu.se/id/publ/832212 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zan, Yanjunu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Div Computat Genet, Dept Clin Sci, SE-75651 Uppsala, Sweden,Carlborg,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University4 aut0 (Swepub:uu)yanza715 |
| 245 | 1 0 | a Genetic Regulation of Transcriptional Variation in Natural Arabidopsis thaliana Accessions |
| 264 | c 2016-08-01 | |
| 264 | 1 | b Oxford University Press (OUP),c 2016 |
| 338 | a electronic2 rdacarrier | |
| 520 | a An increased knowledge of the genetic regulation of expression in Arabidopsis thaliana is likely to provide important insights about the basis of the plant's extensive phenotypic variation. Here, we reanalysed two publicly available datasets with genome-wide data on genetic and transcript variation in large collections of natural A. thaliana accessions. Transcripts from more than half of all genes were detected in the leaf of all accessions, and from nearly all annotated genes in at least one accession. Thousands of genes had high transcript levels in some accessions but no transcripts at all in others and this pattern was correlated with the genome-wide genotype. In total, 2,669 eQTL were mapped in the largest population, and 717 of them were replicated in the other population. 646 cis-eQTLs regulated genes that lacked detectable transcripts in some accessions, and for 159 of these we identified one, or several, common structural variants in the populations that were shown to be likely contributors to the lack of detectable RNA-transcripts for these genes. This study thus provides new insights on the overall genetic regulation of global gene-expression diversity in the leaf of natural A. thaliana accessions. Further, it also shows that strong cis-acting polymorphisms, many of which are likely to be structural variations, make important contributions to the transcriptional variation in the worldwide A. thaliana population. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 653 | a eQTL mapping; RNA sequencing; gene expression; Arabidopsis thaliana; structural variation | |
| 700 | 1 | a Shen, Xiau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh EH16 4UX, Midlothian, Scotland; Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH16 4UX, Midlothian, Scotland; Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,University of Edinburgh,Karolinska Institute4 aut0 (Swepub:slu)52436 |
| 700 | 1 | a Forsberg, Simonu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Div Computat Genet, Dept Clin Sci, SE-75651 Uppsala, Sweden,Carlborg,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University4 aut0 (Swepub:slu)47020 |
| 700 | 1 | a Carlborg, Orjanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Div Computat Genet, Dept Clin Sci, SE-75651 Uppsala, Sweden,Carlborg,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University4 aut0 (Swepub:slu)48083 |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t G3d : Oxford University Press (OUP)g 6:8, s. 2319-2328q 6:8<2319-2328x 2160-1836 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:944773/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.g3journal.org/content/ggg/6/8/2319.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298144 |
| 856 | 4 8 | u https://doi.org/10.1534/g3.116.030874 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134119105 |
| 856 | 4 8 | u https://res.slu.se/id/publ/83221 |
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