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Supersaturation of ...
Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate
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- Zhang, Peng (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
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- Gómez de La Torre, Teresa Zardán (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanoteknologi och funktionella material, Nanotechnology and Functional Materials
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- Welch, Ken, 1968- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Bergström, Christel (author)
- Uppsala universitet,Institutionen för farmaci
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- Strömme, Maria, 1970- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 93, s. 468-474
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Abstract This work investigates whether the solubility of poorly soluble compounds can be improved by using mesoporous magnesium carbonate (MMC) as the drug delivery system. A solvent evaporation method was used to load structurally diverse model drugs (celecoxib, cinnarizine and griseofulvin) into the pores of MMC. The drug-loaded carrier system was then characterized in terms of porosity, crystallinity, and release profiles by a variety of experimental techniques, including X-ray diffraction, nitrogen adsorption analysis, differential scanning calorimetry, infrared spectroscopy, UV absorption spectroscopy, and thermogravimetric analysis. All three drugs were in a non-crystalline state after loading into the pores of MMC. The concentrations of the drugs in solution over time (a measure of the release rates from loaded MMC) were higher than the corresponding concentrations (dissolution rates) of equal amounts of the crystalline drugs. The release rates were five (celecoxib), three (cinnarizine) and two times (griseofulvin) higher than the dissolution rates of their crystalline counterparts. Supersaturation release profiles were also observed; the areas under the concentration-time curves (0â240 min) were 25- (celecoxib), 5- (cinnarizine) and 2-fold (griseofulvin) greater than those of the crystalline drugs. Hence, MMC shows promise as a general drug delivery vehicle for increasing the bioavailability of compounds with dissolution rate- or solubility-limited absorption.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- Mesoporous
- Crystallinity suppression
- Drug release
- Kinetics
- Magnesium carbonate
- Supersaturation
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publication and Content Type
- ref (subject category)
- art (subject category)
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