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The chaperone co-in...
The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
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- Salah, Heba (author)
- Uppsala universitet,Klinisk neurofysiologi,Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.
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- Li, Meishan (author)
- Karolinska Institutet
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- Cacciani, Nicola (author)
- Karolinska Institutet
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- Gastaldello, Stefano (author)
- Karolinska Institutet
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- Ogilvie, Hannah (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.
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- Akkad, Hazem (author)
- Karolinska Institutet
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- Namuduri, Arvind Venkat (author)
- Karolinska Institutet
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- Morbidoni, Valeria (author)
- Univ Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy.
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- Artemenko, Konstantin A. (author)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab
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- Balogh, Gabor (author)
- Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary.
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- Martinez-Redondo, Vicente (author)
- Karolinska Institutet
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- Jannig, Paulo (author)
- Karolinska Institutet
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- Hedström, Yvette (author)
- Karolinska Institutet
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- Dworkin, Barry (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.;Penn State Univ, Dept Neurosci, Hershey, PA 17033 USA.
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA.;Binzhou Med Univ, Precis Med, Yantai 264003, Shandong, Peoples R China.
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- Ruas, Jorge (author)
- Karolinska Institutet
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- Vigh, Laszlo (author)
- Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary.
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- Salviati, Leonardo (author)
- Univ Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy.
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- Larsson, Lars (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2016
- 2016
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 8:350
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Ventilation-induced diaphragm dysfunction (VIDD) is a marked decline in diaphragm function in response to mechanical ventilation, which has negative consequences for individual patients' quality of life and for the health care system, but specific treatment strategies are still lacking. We used an experimental intensive care unit (ICU) model, allowing time-resolved studies of diaphragm structure and function in response to long-term mechanical ventilation and the effects of a pharmacological intervention (the chaperone co-inducer BGP-15). The marked loss of diaphragm muscle fiber function in response to mechanical ventilation was caused by post-translational modifications (PTMs) of myosin. In a rat model, 10 days of BGP-15 treatment greatly improved diaphragm muscle fiber function (by about 100%), although it did not reverse diaphragm atrophy. The treatment also provided protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. Thus, BGP-15 may offer an intervention strategy for reducing VIDD in mechanically ventilated ICU patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Salah, Heba
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Li, Meishan
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Cacciani, Nicola
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Gastaldello, Ste ...
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Ogilvie, Hannah
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Akkad, Hazem
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Namuduri, Arvind ...
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Morbidoni, Valer ...
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Artemenko, Konst ...
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Balogh, Gabor
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Martinez-Redondo ...
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Jannig, Paulo
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Hedström, Yvette
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Dworkin, Barry
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Bergquist, Jonas
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Ruas, Jorge
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Vigh, Laszlo
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Salviati, Leonar ...
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Larsson, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Uppsala University
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Karolinska Institutet