SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:uu-304099"
 

Search: id:"swepub:oai:DiVA.org:uu-304099" > Performance and Val...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation

Oldgren, Jonas (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Hijazi, Ziad (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Lindbäck, Johan (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
show more...
Alexander, John H (author)
Connolly, Stuart J (author)
Eikelboom, John W (author)
Ezekowitz, Michael D (author)
Granger, Christopher B (author)
Hylek, Elaine M (author)
Lopes, Renato D (author)
Siegbahn, Agneta (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation
Yusuf, Salim (author)
Wallentin, Lars (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
show less...
 (creator_code:org_t)
2016
2016
English.
In: Circulation. - 0009-7322 .- 1524-4539. ; 134:22, s. 1697-1707
Related links:
https://urn.kb.se/re...
show more...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • BACKGROUND: -Atrial fibrillation (AF) is associated with increased but variable risk of stroke. Our aim was to validate the recently developed biomarker-based ABC-stroke risk score and compare its performance with the CHA2DS2VASc and ATRIA risk scores.METHODS: -ABC-stroke score includes Age, Biomarkers (NT-proBNP and high-sensitivity [hs] troponin [cTn]), and Clinical history (prior stroke). This validation was based on 8,356 patients, 16,137 person-years of follow-up, and 219 adjudicated stroke or systemic embolic (SE) events in anticoagulated patients with AF in the RE-LY study. Levels of NT-proBNP, hs-cTnT, and hs-cTnI were determined in plasma samples obtained at study entry.RESULTS: -The ABC-stroke score was well calibrated with 0.76 stroke/SE events per 100 person-years in the predefined low (<1%/year) risk group, 1.48 in the medium (1-2%/year) risk group, and 2.60 in the high (>2%/year) risk group for the ABC-stroke score with hs-cTnT. Hazard ratios for stroke/SE were 1.95 for medium versus low risk, and 3.44 for high versus low risk groups. ABC-stroke score achieved C indices of 0.65 with both hs-cTnT and hs-cTnI, as compared with 0.60 for CHA2DS2VASc (p=0.004 for hs-cTnT and p=0.022 hs-cTnI) and 0.61 for ATRIA scores (p=0.005 hs-cTnT and p=0.034 for hs-cTnI).CONCLUSIONS: -The biomarker-based ABC-stroke score was well calibrated and consistently performed better than both the CHA2DS2VASc and ATRIA stroke scores. The ABC score should be considered an improved decision support tool in the care of patients with AF.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

anticoagulation
atrial fibrillation
models
cardiovascular
prevention and control
risk assessment
stroke

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view