Sökning: id:"swepub:oai:DiVA.org:uu-304148" > The infectious part...
Fältnamn | Indikatorer | Metadata |
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000 | 03870naa a2200457 4500 | |
001 | oai:DiVA.org:uu-304148 | |
003 | SwePub | |
008 | 161003s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3041482 URI |
024 | 7 | a https://doi.org/10.1038/srep331702 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Okamoto, Kentau Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)kenok266 |
245 | 1 0 | a The infectious particle of insect-borne totivirus-like Omono River virus has raised ridges and lacks fibre complexes |
264 | c 2016-09-12 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper describes electron cryo-microscopy (cryoEM) structures for the intact OmRV virion to 8.9 angstrom resolution and the structure of the empty virus-like-particle, that lacks RNA, to 8.3 angstrom resolution. The icosahedral capsid contains 120-subunits and resembles another closely related arthropod-borne totivirus-like virus, the infectious myonecrosis virus (IMNV) from shrimps. Both viruses have an elevated plateau around their icosahedral 5-fold axes, surrounded by a deep canyon. Sequence and structural analysis suggests that this plateau region is mainly composed of the extended C-terminal region of the capsid proteins. In contrast to IMNV, the infectious form of OmRV lacks extensive fibre complexes at its 5-fold axes as directly confirmed by a contrast-enhancement technique, using Zernike phase-contrast cryo-EM. Instead, these fibre complexes are replaced by a short "plug" structure at the five-fold axes of OmRV. OmRV and IMNV have acquired an extracellular phase, and the structures at the five-fold axes may be significant in adaptation to cell-to-cell transmission in metazoan hosts. | |
650 | 7 | a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng |
700 | 1 | a Miyazaki, Naoyukiu Natl Inst Physiol Sci, Okazaki, Aichi, Japan.4 aut |
700 | 1 | a Larsson, Daniel S. D.u Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)dalar193 |
700 | 1 | a Kobayashi, Daisukeu Natl Inst Infect Dis, Dept Med Entomol, Tokyo, Japan.4 aut |
700 | 1 | a Svenda, Martinu Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)msv31659 |
700 | 1 | a Mühlig, Kerstinu Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)kermu539 |
700 | 1 | a Maia, Filipe R. N. C.u Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)fimai103 |
700 | 1 | a Gunn, Laura H.u Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)laugu236 |
700 | 1 | a Isawa, Haruhikou Natl Inst Infect Dis, Dept Med Entomol, Tokyo, Japan.4 aut |
700 | 1 | a Kobayashi, Mutsuou Natl Inst Infect Dis, Dept Med Entomol, Tokyo, Japan.4 aut |
700 | 1 | a Sawabe, Kyokou Natl Inst Infect Dis, Dept Med Entomol, Tokyo, Japan.4 aut |
700 | 1 | a Murata, Kazuyoshiu Natl Inst Physiol Sci, Okazaki, Aichi, Japan.4 aut |
700 | 1 | a Hajdu, Janosu Uppsala universitet,Molekylär biofysik4 aut0 (Swepub:uu)janohajd |
710 | 2 | a Uppsala universitetb Molekylär biofysik4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 6q 6x 2045-2322 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1014955/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/srep33170.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304148 |
856 | 4 8 | u https://doi.org/10.1038/srep33170 |
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