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Arterial spin label...
Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
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- Fällmar, David (author)
- Uppsala universitet,Radiologi
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- Haller, Sven (author)
- Uppsala universitet,Radiologi,Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany.; Univ Geneva, Fac Med, Geneva, Switzerland.; Affidea CDRC Ctr Diagnost Radiol Carouge, Carouge, Switzerland.
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- Lilja, Johan (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Hermes Med Solut, Stockholm, Sweden
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- Danfors, Torsten (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Tolboom, Nelleke (author)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
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- Egger, Karl (author)
- Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany
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- Kellner, Elias (author)
- Univ Freiburg, Dept Radiol, Med Ctr, Fac Med,Med Phys, Freiburg, Germany
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- Croon, Philip M (author)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
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- Verfaillie, Sander C J (author)
- Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
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- van Berckel, Bart N M (author)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
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- Ossenkoppele, Rik (author)
- Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
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- Barkhof, Frederik (author)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands.; UCL, Inst Neurol & Healthcare Engn, London, England.
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2017-04-03
- 2017
- English.
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In: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 27:10, s. 4237-4246
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Abstract
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- OBJECTIVE: Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET.METHODS: Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis.RESULTS: Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168).CONCLUSION: ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET.KEY POINTS: • ASL-based Z-maps yielded high specificity and positive predictive value in neurodegenerative dementia. • ASL-based Z-maps had significantly lower sensitivity compared to FDG-PET-based Z-maps. • FDG-PET might be reserved for ASL-negative cases where clinical suspicion persists. • Findings were similar at two study sites.
Keyword
- 18F-FDG
- Arterial spin labeling MRI
- Dementia
- Neurodegenerative
- Visual assessment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fällmar, David
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Haller, Sven
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Lilja, Johan
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Danfors, Torsten
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Kilander, Lena
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Tolboom, Nelleke
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show more...
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Egger, Karl
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Kellner, Elias
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Croon, Philip M
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Verfaillie, Sand ...
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van Berckel, Bar ...
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Ossenkoppele, Ri ...
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Barkhof, Frederi ...
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Larsson, Elna-Ma ...
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European Radiolo ...
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Uppsala University