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Patients with lymphatic malformations who receive the immunostimulant OK-432 experience excellent long-term outcomes
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- Ghaffarpour, N (author)
- Karolinska Institutet
- Petrini, B (author)
- Svensson, L A (author)
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- Claesson, G (author)
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- (creator_code:org_t)
- 2015-07-14
- 2015
- English.
- In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 104:11, s. 1169-73
- Journal article (peer-reviewed)
Abstract
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- AIM: Sclerotherapy is the primary treatment for lymphatic malformations. The aim of this study was to evaluate the long-term outcome in patients with lymphatic malformations treated with the immunostimulant OK-432 as a sclerosant.METHODS: Between 1998 and 2013, we enrolled 131 of 138 eligible patients treated with OK-432 for lymphatic malformations in a retrospective study. The malformations were categorised according to the International Society for the Study of Vascular Anomalies. The outcome was assessed with a clinical examination and a questionnaire.RESULTS: The lymphatic malformations were localised to the head/neck (60%), the trunk (20%) and the extremities (6%) or involved with more than one region (14%). Patients with microcystic (10%), macrocystic (21%) and mixed lymphatic malformations (69%) underwent a median number of three, two and two injection treatments, respectively. The median age at the first injection was 3.4 years. Good or excellent clinical outcomes were seen in 70% of the patients. The number of injections, previous treatment and lesion localisation, but not time to follow-up and cyst size, predicted the clinical outcome.CONCLUSION: OK-432 treatment resulted in a successful outcome in 70% of patients with lymphatic malformations. The long-term outcome was comparable to the short-term outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Lymphatic malformation
- OK-432
- Sclerotherapy
- Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Ghaffarpour, N
- Petrini, B
- Svensson, L A
- Boman, K
- Wester, T
- Claesson, G
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- and Surgery
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- Acta Paediatrica
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- Uppsala University
- Karolinska Institutet
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