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The 99th percentile...
The 99th percentile and imprecision of point-of-care cardiac troponin I in comparison to central laboratory tests in a large reference population
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Greiser, Anne (author)
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Winter, Theresa (author)
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Mahfoud, Hala (author)
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- Kallner, Anders (author)
- Karolinska Institutet
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Ittermann, Till (author)
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Masuch, Annette (author)
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- Lubenow, Norbert (author)
- Uppsala universitet,Klinisk immunologi
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Kohlmann, Thomas (author)
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Greinacher, Andreas (author)
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Nauck, Matthias (author)
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Petersmann, Astrid (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Clinical Biochemistry. - : Elsevier BV. - 0009-9120 .- 1873-2933. ; 50:18, s. 1198-1202
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES: Determination of cardiac troponin (cTn) is central in the emergency department (ED) for the diagnosis of myocardial infarction. In view of adverse effects of long waiting time on patient outcome, implementation of point-of-care-testing (POCT) is suggested if the turn-around-time is longer than 60min. The present study aimed to determine the 99th percentile and imprecision of two POCT in a healthy population measuring cTnI and cTnT and compare these analytical characteristics against three central laboratory test (CLT) for cTnI.DESIGN & METHODS: CTnI and cTnT were determined in parallel by means of the AQT90 FLEX analyzer in about 2250 plasma samples from individuals with known health status. Results were compared to previously determined performance data of three CLT.RESULTS: The 99th percentile of cTnI in the POCT was determined at 19ng/L, the lowest concentration with an imprecision of 10% was reached at 22ng/L while an imprecision of 20% was reached at 13ng/L. Age, sex, or physical activity did not affect the 99th percentile of cTnI. Compared to CLT the AQT90 cTnI POCT the analytical performance was equivalent. The cTnT POCT could not be assessed due a considerable number of high values and an inadequate imprecision profile.CONCLUSION: While the cTnI POCT showed analytical performance comparable to CLT, the results of the cTnT assay on the same device did not suffice to determine a reliable 99th percentile. The present evaluation supports the usage of the cTnI POCT, but application of the cTnT POCT needs further evaluation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- 99th reference percentile
- AQT90
- Analytical performance
- Cardiac troponin I and T
- Point-of-care
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Greiser, Anne
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Winter, Theresa
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Mahfoud, Hala
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Kallner, Anders
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Ittermann, Till
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Masuch, Annette
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show more...
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Lubenow, Norbert
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Kohlmann, Thomas
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Greinacher, Andr ...
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Nauck, Matthias
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Petersmann, Astr ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Clinical Biochem ...
- By the university
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Uppsala University
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Karolinska Institutet