id:"swepub:oai:DiVA.org:uu-344303"
Sökning: id:"swepub:oai:DiVA.org:uu-344303" > Equine in vivo-deri...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04003naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-344303 | |
| 003 | SwePub | |
| 008 | 180306s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3443032 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jchromb.2017.12.0102 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hansson, Annelieu Uppsala universitet,Analytisk vetenskap4 aut0 (Swepub:uu)annha905 |
| 245 | 1 0 | a Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. |
| 264 | 1 | b Elsevier BV,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a LGD-4033 has been found in human doping control samples and has the potential for illicit use in racehorses as well. It belongs to the pharmacological class of selective androgen receptor modulators (SARMs) and can stimulate muscle growth, much like anabolic steroids. However, SARMs have shown superior side effect profiles compared to anabolic steroids, which arguably makes them attractive for use by individuals seeking an unfair advantage over their competitors. The purpose of this study was to investigate the metabolites formed from LGD-4033 in the horse in order to find suitable analytical targets for doping controls. LGD-4033 was administered to three horses after which plasma and urine samples were collected and analyzed for metabolites using ultra high performance liquid chromatography coupled to a high resolution mass spectrometer. In horse urine, eight metabolites, both phase I and phase II, were observed most of which had not been described in other metabolic systems. Six of these were also detected in plasma. The parent compound was detected in plasma, but not in non-hydrolyzed urine. The longest detection times were observed for unchanged LGD-4033 in plasma and in urine hydrolyzed with β-glucuronidase and is thus suggested as the analytical target for doping control in the horse. The metabolite profile determined in the horse samples was also compared to those of human urine and fungal incubate from Cunninghamella elegans. The main human metabolite, dihydroxylated LGD-4033, was detected in the horse samples and was also produced by the fungus. However, it was a not a major metabolite for horse and fungus, which highlights the importance of performing metabolism studies in the species of interest. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
| 653 | a Doping | |
| 653 | a LGD-4033 | |
| 653 | a Horse | |
| 653 | a Mass Spectrometry | |
| 653 | a Metabolite | |
| 653 | a SARM | |
| 653 | a Selective Androgen Receptor Modulator | |
| 700 | 1 | a Knych, Heather4 aut |
| 700 | 1 | a Stanley, Scott4 aut |
| 700 | 1 | a Berndtson, Emmau Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden4 aut |
| 700 | 1 | a Jackson, Liorau Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden4 aut |
| 700 | 1 | a Bondesson, Ulfu Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden4 aut0 (Swepub:uu)ulfbonde |
| 700 | 1 | a Thevis, Mario4 aut |
| 700 | 1 | a Hedeland, Mikaelu Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, SE-75651 Uppsala, Sweden4 aut0 (Swepub:uu)mikahede |
| 710 | 2 | a Uppsala universitetb Analytisk vetenskap4 org |
| 773 | 0 | t Journal of chromatography. Bd : Elsevier BVg 1074-1075, s. 91-98q 1074-1075<91-98x 1570-0232x 1873-376X |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-344303 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jchromb.2017.12.010 |
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