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Nucleases as molecu...
Nucleases as molecular targets for cancer diagnosis
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- Balian, Alien (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Hernandez, Frank (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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(creator_code:org_t)
- 2021-11-22
- 2021
- Engelska.
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Ingår i: Biomarker Research. - : BMC. - 2050-7771. ; 9:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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visa fler...
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https://biomarkerres...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioteknisk apparatteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioengineering Equipment (hsv//eng)
Nyckelord
- Nuclease; Nuclease activity; cancer biomarkers; cancer diagnostics; Nucleic acid probes; novel diagnostics
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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