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Glucose, lipids and...
Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours : a prospective study in the Swedish AMORIS cohort
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- Bosco, Cecilia (författare)
- Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England.
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- Garmo, Hans (författare)
- Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England.;Reg Canc Ctr, Uppsala, Sweden.
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- Hammar, Niklas (författare)
- Karolinska Institutet
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- Walldius, Göran (författare)
- Karolinska Institutet
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- Jungner, Ingmar (författare)
- Karolinska Inst, Dept Clin Epidemiol, Stockholm, Sweden.;CALAB Res, Stockholm, Sweden.
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- Malmström, Håkan (författare)
- Karolinska Institutet
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England.
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- Van Hemelrijck, Mieke (författare)
- Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England.;Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
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Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England Kings Coll London Res Oncol, Guys Hosp, Kings Coll London Translat Oncol & Urol Res TOUR, Div Canc Studies, 3rd Floor, London SE1 9RT, England.;Reg Canc Ctr, Uppsala, Sweden. (creator_code:org_t)
- 2018-02-20
- 2018
- Engelska.
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Ingår i: BMC Cancer. - : BIOMED CENTRAL LTD. - 1471-2407. ; 18
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmccancer.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Improvements in detection and treatment of prostate cancer (PCa) translate into more men living with PCa, who are therefore potentially at risk of a secondly diagnosed primary tumour (SDPTs). Little is known about potential biochemical mechanisms linking PCa with the occurrence of SDPTs. The current study aims to investigate serum biomarkers of glucose and lipid metabolism and gamma-glutamyl transferase (GGT) measured prior to PCa diagnosis and their association with the occurrence of SDPTS.Methods: From the Swedish AMORIS cohort, we selected all men diagnosed with PCa between 1996 and 2011, with at least one of the five biomarkers of interest (glucose, fructosamine, triglycerides, total cholesterol (TC), GGT) measured on average 16 years before PCa diagnosis (n = 10,791). Multivariate Cox proportional hazards models were used to determine hazard ratios (HR) for risk of SDPTs (overall and subtypes) by levels of the five biomarkers. Effect modification of treatment was assessed.Results: 811 SDPTS were diagnosed during a median follow-up time of 5 years. Elevated levels of triglycerides (HR: 1.37, 95% CI: 1.17-1.60), TC (HR: 1.22, 95% CI: 1.04-1.42) and GGT (HR: 1.32, 95% CI: 1.02-1.71) were associated with an increased risk of SDPTs. Risk of SDPTs subtypes varied by biomarkers.Conclusion: Elevated levels of biomarkers of lipid metabolism and GGT measured prior to PCa diagnosis were associated with an increased risk of SDPTs, suggesting a potential common biochemical background for development of PCa and SDPTs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- Second primary tumours
- Triglycerides
- Gamma-glutamyl transferase
- Glucose
- Total cholesterol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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