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Defective endotheli...
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
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- Laviña, Bàrbara (author)
- Uppsala universitet,Vaskulärbiologi
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- Castro, Marco (author)
- Uppsala universitet,Vaskulärbiologi
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- Niaudet, Colin (author)
- Uppsala universitet,Vaskulärbiologi
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- Cruys, Bert (author)
- VIB, Vesalius Res Ctr, Lab Angiogenesis & Vasc Metab, Leuven, Belgium; Katholieke Univ Leuven, Dept Oncol, Lab Angiogenesis & Vasc Metab, Leuven, Belgium
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- Álvarez-Aznar, Alberto (author)
- Uppsala universitet,Vaskulärbiologi
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- Carmeliet, Peter (author)
- VIB, Vesalius Res Ctr, Lab Angiogenesis & Vasc Metab, Leuven, Belgium; Katholieke Univ Leuven, Dept Oncol, Lab Angiogenesis & Vasc Metab, Leuven, Belgium
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- Bentley, Katie (author)
- Uppsala universitet,Vaskulärbiologi,Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Vasc Biol Res, Computat Biol Lab, Boston, MA USA
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- Brakebusch, Cord (author)
- Univ Copenhagen, Biotech Res & Innovat Ctr, Copenhagen, Denmark
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- Betsholtz, Christer (author)
- Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Dept Med Huddinge, ICMC, Stockholm, Sweden
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- Gängel, Konstantin (author)
- Uppsala universitet,Vaskulärbiologi
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(creator_code:org_t)
- 2018-01-01
- 2018
- English.
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In: Development. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 145:13
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Formation and homeostasis of the vascular system requires several coordinated cellular functions, but their precise interplay during development and their relative importance for vascular pathologies remain poorly understood. Here, we investigated the endothelial functions regulated by Cdc42 and their in vivo relevance during angiogenic sprouting and vascular morphogenesis in the postnatal mouse retina. We found that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads to defective endothelial axial polarization and to the formation of severe vascular malformations in capillaries and veins. Tracking of Cdc42-depleted endothelial cells in mosaic retinas suggests that these capillary-venous malformations arise as a consequence of defective cell migration, when endothelial cells that proliferate at normal rates are unable to re-distribute within the vascular network.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Vascular malformations
- Cdc42
- Cell migration
- Endothelial axial polarity
- Angiogenesis
- Proliferation
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Laviña, Bàrbara
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Castro, Marco
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Niaudet, Colin
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Cruys, Bert
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Álvarez-Aznar, A ...
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Carmeliet, Peter
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show more...
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Bentley, Katie
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Brakebusch, Cord
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Betsholtz, Chris ...
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Gängel, Konstant ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Development
- By the university
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Uppsala University
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Karolinska Institutet