Nomenclature for endogenous retrovirus (ERV) loci

Gifford, Robert J. (författare): Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland

Coffin, John M. (författare): Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

Fan, Hung (författare): Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA;Univ Calif Irvine, Canc Res Inst, Irvine, CA 92697 USA

Heidmann, Thierry (författare): Inst Gustave Roussy, CNRS UMR 9196, Dept Mol Physiol & Pathol Infect & Endogenous Ret, F-94805 Villejuif, France

Mayer, Jens (författare): Univ Saarland, Med Fac, Dept Human Genet, Ctr Human & Mol Biol, Homburg, Germany

Stoye, Jonathan (författare): Francis Crick Inst, Mill Hill Lab, Mill Hill, London, England

Tristem, Michael (författare): Imperial Coll London, Silwood Pk Campus,Buckhurst Rd, Ascot SL5 7PY, Berks, England

Johnson, Welkin E. (författare): Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA

(creator_code:org_t)

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Abstract Ämnesord

Stäng

Retroviral integration into germline DNA can result in the formation of a vertically inherited proviral sequence called an endogenous retrovirus (ERV). Over the course of their evolution, vertebrate genomes have accumulated many thousands of ERV loci. These sequences provide useful retrospective information about ancient retroviruses, and have also played an important role in shaping the evolution of vertebrate genomes. There is an immediate need for a unified system of nomenclature for ERV loci, not only to assist genome annotation, but also to facilitate research on ERVs and their impact on genome biology and evolution. In this review, we examine how ERV nomenclatures have developed, and consider the possibilities for the implementation of a systematic approach for naming ERV loci. We propose that such a nomenclature should not only provide unique identifiers for individual loci, but also denote orthologous relationships between ERVs in different species. In addition, we propose that-where possible-mnemonic links to previous, well-established names for ERV loci and groups should be retained. We show how this approach can be applied and integrated into existing taxonomic and nomenclature schemes for retroviruses, ERVs and transposable elements.

Av författaren/redakt...: Gifford, Robert ...; Blomberg, Jonas; Coffin, John M.; Fan, Hung; Heidmann, Thierr ...; Mayer, Jens; visa fler...; Stoye, Jonathan; Tristem, Michael; Johnson, Welkin ...; visa färre...

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