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Serum Parathyroid H...
Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease : A Mendelian Randomization Study
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- Larsson, Susanna C (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi
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- Traylor, Matthew (author)
- Univ Cambridge, Dept Clin Neurosci, Stroke Res Grp, Cambridge, England
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- Markus, Hugh S (author)
- Univ Cambridge, Dept Clin Neurosci, Stroke Res Grp, Cambridge, England
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- Michaëlsson, Karl, 1959- (author)
- Uppsala universitet,Ortopedi
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(creator_code:org_t)
- 2018-09-06
- 2018
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 10:9
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Abstract
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- We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer's disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer's Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97-1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78-0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Alzheimer’s disease
- Mendelian randomization
- parathyroid hormone
- vitamin D
Publication and Content Type
- ref (subject category)
- art (subject category)
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