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Genetic association between adiposity and gout : a Mendelian randomization study
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- Larsson, Susanna C (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden
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- Burgess, Stephen (author)
- Univ Cambridge, MRC Biostat Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England
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- Michaëlsson, Karl, 1959- (author)
- Uppsala universitet,Ortopedi
- (creator_code:org_t)
- 2018-08-04
- 2018
- English.
- In: Rheumatology. - : OXFORD UNIV PRESS. - 1462-0324 .- 1462-0332. ; 57:12, s. 2145-2148
- Journal article (peer-reviewed)
Abstract
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- Objective: To investigate whether overall obesity (as measured by BMI) and abdominal obesity (as measured by waist-to-hip ratio adjusted for BMI) are associated with gout risk and serum urate concentrations using Mendelian randomization.Methods: Single nucleotide polymorphisms associated with BMI (n = 97) and waist-to-hip ratio adjusted for BMI (n = 49) were analysed for association with gout risk in 2115 gout cases and 67 259 controls, and with serum urate concentrations in 110 347 individuals from the Global Urate Genetics Consortium.Results: Genetically higher BMI, but not waist-to-hip ratio adjusted for BMI, was positively associated with risk of gout and serum urate concentrations. Each standard deviation (about 4.6 kg/m(2)) increase in genetically predicted BMI was associated with an odds ratio of gout of 2.24 (95% CI 1.70, 2.95; P = 8.4 x 10(-9)) and with a 0.30 mg/dl (95% CI 0.25, 0.35; P = 1.6 x 10(-36)) increase in serum urate concentrations.Conclusion: These findings provide support that overall obesity may be a risk factor for gout and is associated with higher serum urate concentrations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- adiposity
- body mass index
- gout
- Mendelian randomization
- obesity
- urate
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- ref (subject category)
- art (subject category)
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