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Single-cell RNA seq...
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
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- Tiklova, Katarina (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Björklund, Åsa K. (author)
- Uppsala University,Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Lahti, Laura (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Fiorenzano, Alessandro (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Nolbrant, Sara (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Gillberg, Linda (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Volakakis, Nikolaos (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Yokota, Chika (author)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-17165 Solna, Sweden
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- Hilscher, Markus M. (author)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-17165 Solna, Sweden
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- Hauling, Thomas (author)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-17165 Solna, Sweden
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- Holmstrom, Fredrik (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Joodmardi, Eliza (author)
- Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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- Nilsson, Mats (author)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-17165 Solna, Sweden
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- Parmar, Malin (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Perlmann, Thomas (author)
- Karolinska Institute,Karolinska Institutet,Ludwig Inst Canc Res, Box 240, SE-17177 Stockholm, Sweden;Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden,Ludwig Institute for Cancer Research, Stockholm branch
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(creator_code:org_t)
- 2019-02-04
- 2019
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Abstract
Subject headings
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- Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been intensely studied, not least because their degeneration causes major symptoms in Parkinson's disease. Understanding the diversity of mDA neurons - previously well characterized anatomically - requires a systematic molecular classification at the genome-wide gene expression level. Here, we use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3, a marker for mDA neurons. Analyses include cells isolated during development up until adulthood and the results are validated by histological characterization of newly identified markers. This identifies seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons. Five of them express dopaminergic markers, while two express glutamatergic and GABAergic markers, respectively. Analysis also indicate evolutionary conservation of diversity in humans. This comprehensive molecular characterization will provide a valuable resource for elucidating mDA neuron subgroup development and function in the mammalian brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tiklova, Katarin ...
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Björklund, Åsa K ...
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Lahti, Laura
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Fiorenzano, Ales ...
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Nolbrant, Sara
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Gillberg, Linda
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show more...
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Volakakis, Nikol ...
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Yokota, Chika
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Hilscher, Markus ...
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Hauling, Thomas
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Holmstrom, Fredr ...
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Joodmardi, Eliza
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Nilsson, Mats
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Parmar, Malin
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Perlmann, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Stockholm University
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Karolinska Institutet
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Lund University