SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:uu-390826"
 

Sökning: id:"swepub:oai:DiVA.org:uu-390826" > Endothelial cell cl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004566naa a2200493 4500
001oai:DiVA.org:uu-390826
003SwePub
008190814s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3908262 URI
0247 a https://doi.org/10.1038/s41467-019-10707-x2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Malinverno, Matteou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
2451 0a Endothelial cell clonal expansion in the development of cerebral cavernous malformations
264 c 2019-06-24
264 1b NATURE PUBLISHING GROUP,c 2019
338 a electronic2 rdacarrier
520 a Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes. Familial CCM follows a two-hit mechanism similar to that of tumour suppressor genes, while in sporadic cavernomas only a small fraction of endothelial cells shows mutated CCM genes. We reported that in mouse models and in human patients, endothelial cells lining the lesions have different features from the surrounding endothelium, as they express mesenchymal/stem-cell markers. Here we show that cavernomas originate from clonal expansion of few Ccm3-null endothelial cells that express mesenchymal/stem-cell markers. These cells then attract surrounding wild-type endothelial cells, inducing them to express mesenchymal/stem-cell markers and to contribute to cavernoma growth. These characteristics of Ccm3-null cells are reminiscent of the tumour-initiating cells that are responsible for tumour growth. Our data support the concept that CCM has benign tumour characteristics.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Maderna, Claudiou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
7001 a Abu Taha, Abdallahu Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)abdab543
7001 a Corada, Monicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
7001 a Orsenigo, Fabriziou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
7001 a Valentino, Mariaelenau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
7001 a Pisati, Federicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Cogentech Scarl, Histopathol Unit, I-20139 Milan, Italy4 aut
7001 a Fusco, Carmelau Fdn IRCCS Casa Sollievo Sofferenza, Div Med Genet, I-71013 Foggia, Italy4 aut
7001 a Graziano, Paolou Fdn IRCCS Casa Sollievo Sofferenza, Pathol Unit, I-71013 Foggia, Italy4 aut
7001 a Giannotta, Monicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut
7001 a Yu, Qing Cissyu Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China4 aut
7001 a Zeng, Yi Arialu Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China4 aut
7001 a Lampugnani, Maria Graziau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Mario Negri Inst Pharmacol Res, I-20156 Milan, Italy4 aut
7001 a Magnusson, Peetra U.u Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)petrmagn
7001 a Dejana, Elisabettau Uppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Univ Milan, Sch Med, Dept Oncol & Haematooncol, I-20122 Milan, Italy4 aut0 (Swepub:uu)elide443
7102 a FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italyb Vaskulärbiologi4 org
7730 t Nature Communicationsd : NATURE PUBLISHING GROUPg 10q 10x 2041-1723
8564 u https://doi.org/10.1038/s41467-019-10707-xy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1342897/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41467-019-10707-x.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390826
8564 8u https://doi.org/10.1038/s41467-019-10707-x

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy