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Successful oral del...
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
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- Boyd, Ben J. (author)
- Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic, Australia
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- Bergström, Christel, 1973- (author)
- Uppsala universitet,Institutionen för farmaci
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- Vinarov, Zahari (author)
- Univ Sofia, Fac Chem & Pharm, Sofia, Bulgaria
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- Kuentz, Martin (author)
- Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland
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- Brouwers, Joachim (author)
- Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium
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- Augustijns, Patrick (author)
- Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium
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- Brandl, Martin (author)
- Univ Southern Denmark, Dept Phys Chem & Pharm, Odense, Denmark
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- Bernkop-Schnürch, Andreas (author)
- Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria
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- Shrestha, Neha (author)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Brussels, Belgium
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- Preat, Veronique (author)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Brussels, Belgium
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- Müllertz, Anette (author)
- Univ Copenhagen, Physiol Pharmaceut, Copenhagen, Denmark
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- Bauer-Brandl, Annette (author)
- Univ Southern Denmark, Dept Phys Chem & Pharm, Odense, Denmark
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- Jannin, Vincent (author)
- Gattefosse SAS, St Priest, France
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(creator_code:org_t)
- ELSEVIER, 2019
- 2019
- English.
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In: European Journal of Pharmaceutical Sciences. - : ELSEVIER. - 0928-0987 .- 1879-0720. ; 137
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Abstract
Subject headings
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- Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Poorly water-soluble drugs
- Formulation
- Bioavailability
- Drug delivery
- Lipid formulations
- Solid state
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Boyd, Ben J.
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Bergström, Chris ...
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Vinarov, Zahari
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Kuentz, Martin
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Brouwers, Joachi ...
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Augustijns, Patr ...
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show more...
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Brandl, Martin
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Bernkop-Schnürch ...
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Shrestha, Neha
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Preat, Veronique
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Müllertz, Anette
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Bauer-Brandl, An ...
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Jannin, Vincent
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University