SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:uu-396188"
 

Sökning: id:"swepub:oai:DiVA.org:uu-396188" > Computational model...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004516naa a2200517 4500
001oai:DiVA.org:uu-396188
003SwePub
008191030s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141036703
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3961882 URI
0247 a https://doi.org/10.1080/10408444.2019.15841532 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410367032 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Ganguly, Koustavu Karolinska Institutet4 aut
2451 0a Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients :b identification of gaps in knowledge and data
264 c 2019-04-23
264 1b TAYLOR & FRANCIS LTD,c 2019
338 a electronic2 rdacarrier
520 a Computational modeling together with experimental data are essential to assess the risk for particulate matter mediated lung toxicity and to predict the efficacy, safety and fate of aerosolized drug molecules used in inhalation therapy. In silico models are widely used to understand the deposition, distribution, and clearance of inhaled particles and aerosols in the human lung. Exacerbations of chronic obstructive pulmonary disease (COPD) have been reported due to increased particulate matter related air pollution episodes. Considering the profound functional, anatomical and structural changes occurring in COPD lungs, the relevance of the existing in silico models for mimicking diseased lungs warrants reevaluation. Currently available computational modeling tools were developed for the healthy adult (male) lung. Here, we analyze the major alterations occurring in the airway structure, anatomy and pulmonary function in the COPD lung, as compared to the healthy lung. We also scrutinize the various physiological and particle characteristics that influence particle deposition, distribution and clearance in the lung. The aim of this review is to evaluate the availability of the fundamental knowledge and data required for modeling particle deposition in a COPD lung departing from the existing healthy lung models. The extent to which COPD pathophysiology may affect aerosol deposition depends on the relative contribution of several factors such as altered lung structure and function, bronchoconstriction, emphysema, loss of elastic recoil, altered breathing pattern and altered liquid volumes that warrant consideration while developing physiologically relevant in silico models.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Emphysema
653 a chronic bronchitis
653 a air pollution
653 a inhalation
653 a particle
653 a COPD
653 a in silico
7001 a Carlander, Ulrikau Karolinska Institutet4 aut
7001 a Garessus, Estella D. G.u Karolinska Inst, Inst Environm Med, Integrat Toxicol, Stockholm, Sweden4 aut
7001 a Fridén, Markusu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,AstraZeneca, Resp Inflammat & Autoimmun IMED Biotech Unit, Gothenburg, Sweden4 aut0 (Swepub:uu)mafri535
7001 a Eriksson, Ulf G.u AstraZeneca, Quantitat Clin Pharmacol, IMED Biotech Unit, Early Clin Dev, Gothenburg, Sweden4 aut
7001 a Tehler, Ulrikau AstraZeneca, IMED Biotech Unit, Early Prod Dev, Pharmaceut Sci, Gothenburg, Sweden4 aut
7001 a Johanson, Gunnaru Karolinska Institutet4 aut
7102 a Karolinska Institutetb Karolinska Inst, Inst Environm Med, Integrat Toxicol, Stockholm, Sweden4 org
7730 t Critical reviews in toxicologyd : TAYLOR & FRANCIS LTDg 49:2, s. 160-173q 49:2<160-173x 1040-8444x 1547-6898
8564 u https://doi.org/10.1080/10408444.2019.1584153y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1366793/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.tandfonline.com/doi/pdf/10.1080/10408444.2019.1584153?needAccess=true
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396188
8564 8u https://doi.org/10.1080/10408444.2019.1584153
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141036703

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy