id:"swepub:oai:DiVA.org:uu-397594"
Search: id:"swepub:oai:DiVA.org:uu-397594" > Assessing Causality...
- 1 of 1
- Previous record
- Next record
- To hitlist
Assessing Causality in Associations of Serum Calcium and Magnesium Levels With Heart Failure : A Two-Sample Mendelian Randomization Study
-
- Helte, Emilie (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden
-
- Akesson, Agneta (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden
-
- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr & Cardiovasc Epidemiol, Stockholm, Sweden
- (creator_code:org_t)
- 2019-10-23
- 2019
- English.
- In: Frontiers in Genetics. - : FRONTIERS MEDIA SA. - 1664-8021. ; 10
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Evidence from observational studies suggests that increased exposure to calcium may increase the risk of coronary heart disease and stroke whereas magnesium might have a protective effect on disease risk. However, studies of the associations of these minerals with heart failure are scarce and limited by potential biases introduced by confounding and reverse causality. We applied a two-sample Mendelian randomization design using summary estimates to assess whether serum calcium and magnesium concentrations are causally associated with heart failure. Summary statistics data were collected for seven and six single-nucleotide polymorphisms associated with calcium and magnesium, respectively, from the hitherto largest genome-wide association studies on these minerals. Corresponding summary statistics for genetic associations with heart failure were available from publicly available data based on the UK Biobank study and based on participants of European ancestry. The findings showed that neither serum calcium nor magnesium concentrations were associated with heart failure. In the standard inverse-variance weighted analysis, the odds ratios of heart failure per genetically predicted one standard deviation increase in mineral concentrations were 0.89 (95% confidence interval 0.67-1.17; p = 0.41) for serum calcium and 0.89 (95% confidence interval 0.72-1.10; p = 0.28) for serum magnesium. Results were robust in sensitivity analyses, including the weighted median and Mendelian randomization Egger analyses. In conclusion, these findings do not support previous findings suggesting a link between serum calcium and magnesium and heart failure, but this study was underpowered to detect weak associations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- calcium
- heart failure
- magnesium
- minerals
- Mendelian randomization
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Frontiers in Genetics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Helte, Emilie
- Akesson, Agneta
- Larsson, Susanna ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Frontiers in Gen ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
