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R3hdml regulates sa...
R3hdml regulates satellite cell proliferation and differentiation
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- Sakamoto, Kenichi (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Furuichi, Yasuro (author)
- Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
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- Yamamoto, Masashi (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Takahashi, Megumi (author)
- Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
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- Akimoto, Yoshihiro (author)
- Kyorin Univ, Sch Med, Dept Anat, Tokyo, Japan
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- Ishikawa, Takahiro (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
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- Shimizu, Takahiko (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Natl Ctr Geriatr & Gerontol, Aging Stress Response Res Project Team, Obu, Aichi, Japan
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- Fujimoto, Masanori (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Takada-Watanabe, Aki (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Hayashi, Aiko (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Mita, Yoshitaka (author)
- Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
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- Manabe, Yasuko (author)
- Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
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- Fujii, Nobuharu L. (author)
- Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
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- Ishibashi, Ryoichi (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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- Maezawa, Yoshiro (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
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- Betsholtz, Christer (author)
- Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Novum, ICMC, Huddinge, Sweden
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- Yokote, Koutaro (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
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- Takemoto, Minoru (author)
- Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Int Univ Hlth & Welf, Dept Diabet Metab & Endocrinol, Sch Med, Chiba, Japan
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(creator_code:org_t)
- 2019-09-16
- 2019
- English.
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In: EMBO Reports. - : John Wiley & Sons. - 1469-221X .- 1469-3178. ; 20:11
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml KO mice compared to control mice. Expression of R3hdml increases during muscle regeneration in response to cardiotoxin (CTX)-induced muscle injury. Recovery of handgrip strength after CTX injection was significantly impaired in R3hdml KO mice, which is rescued by R3hdml. Our results indicate that R3hdml is required for skeletal muscle development, regeneration, and, in particular, satellite cell proliferation and differentiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- R3hdml
- sarcopenia
- satellite cell
- skeletal muscle
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sakamoto, Kenich ...
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Furuichi, Yasuro
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Yamamoto, Masash ...
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Takahashi, Megum ...
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Akimoto, Yoshihi ...
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Ishikawa, Takahi ...
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Shimizu, Takahik ...
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Fujimoto, Masano ...
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Takada-Watanabe, ...
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Hayashi, Aiko
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Mita, Yoshitaka
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Manabe, Yasuko
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Fujii, Nobuharu ...
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Ishibashi, Ryoic ...
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Maezawa, Yoshiro
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Betsholtz, Chris ...
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Yokote, Koutaro
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Takemoto, Minoru
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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EMBO Reports
- By the university
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Uppsala University
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Karolinska Institutet