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Prediction of Resid...
Prediction of Residual Risk by Ceramide-Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy
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- Hilvo, Mika (författare)
- Zora Biosci Oy, Tietotie 2C, Espoo 02150, Finland.
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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- Ghukasyan, Tatevik (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clin Res Ctr, Uppsala, Sweden.
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- Held, Claes, 1956- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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- Kauhanen, Dimple (författare)
- Zora Biosci Oy, Tietotie 2C, Espoo 02150, Finland.
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- Jylha, Antti (författare)
- Zora Biosci Oy, Tietotie 2C, Espoo 02150, Finland.
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- Lindbäck, Johan (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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- Granger, Christopher B. (författare)
- Duke Univ, Med Ctr, Durham, NC USA.
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- Koenig, Wolfgang (författare)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Munchen Germany, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.
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- Stewart, Ralph A. H. (författare)
- Auckland City Hosp, N Green Lane Cardiovasc Serv, Auckland, New Zealand.;Univ Auckland, Auckland, New Zealand.
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- White, Harvey (författare)
- Auckland City Hosp, N Green Lane Cardiovasc Serv, Auckland, New Zealand.;Univ Auckland, Auckland, New Zealand.
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- Laaksonen, Reijo (författare)
- Zora Biosci Oy, Tietotie 2C, Espoo 02150, Finland.;Univ Tampere, Finnish Cardiovasc Res Ctr, Tampere, Finland.;Tampere Univ Hosp, Finnish Clin Biobank Tampere, Tampere, Finland.
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Zora Biosci Oy, Tietotie 2C, Espoo 02150, Finland Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- WILEY, 2020
- 2020
- Engelska.
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Ingår i: Journal of the American Heart Association. - : WILEY. - 2047-9980. ; 9:10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Identification of patients with stable coronary heart disease who are at significant residual risk could be helpful for targeted prevention. Our aim was to determine the prognostic value of the recently introduced ceramide-and phospholipid-based risk score, the Cardiovascular Event Risk Test (CERT2), in patients with stable coronary heart disease on optimal medical therapy and to identify biological processes that contribute to the CERT2 score. METHODS AND RESULTS: Plasma samples (n=11 222) obtained from the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial were analyzed using a tandem liquid chromatography-mass spectrometry method. STABILITY was a trial in patients with stable coronary heart disease randomized to the lipoprotein-associated phospholipase A2 inhibitor darapladib or placebo on optimized medical therapy at baseline, with a median follow-up of 3.7 years. Hazard ratios per SD for the CERT2 risk score were 1.32 (95% CI, 1.25-1.39) for major adverse cardiovascular event, 1.47 (95% CI, 1.35-1.59) for cardiovascular death, 1.32 (95% CI, 1.16-1.49) for stroke, 1.23 (95% CI, 1.14-1.33) for myocardial infarction, and 1.56 (95% CI, 1.39-1.76) for hospitalization due to heart failure, when adjusted for traditional cardiovascular risk factors. CERT2 showed correlation (P<0.001, r>0.2) with inflammatory markers high-sensitivity C-reactive protein, interleukin 6, the heart failure marker N-terminal pro-B-type natriuretic peptide, and low-density lipoprotein cholesterol. After also adjusting for levels of other prognostic biomarkers, the CERT2 score was still independently related to the risk of cardiovascular death but not to nonfatal events. CONCLUSIONS: The CERT2 risk score can detect residual risk in patients with stable coronary heart disease and is associated with biomarkers indicating inflammation, myocardial necrosis, myocardial dysfunction, renal dysfunction, and dyslipidemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- biomarker
- cardiovascular
- CERT2
- inflammation
- lipid
- risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hilvo, Mika
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Wallentin, Lars, ...
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Ghukasyan, Tatev ...
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Held, Claes, 195 ...
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Kauhanen, Dimple
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Jylha, Antti
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Lindbäck, Johan
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Siegbahn, Agneta ...
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Granger, Christo ...
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Koenig, Wolfgang
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Stewart, Ralph A ...
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White, Harvey
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Laaksonen, Reijo
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