id:"swepub:oai:DiVA.org:uu-425691"
Search: id:"swepub:oai:DiVA.org:uu-425691" > Design, synthesis a...
- 1 of 1
- Previous record
- Next record
- To hitlist
Design, synthesis and biological evaluation of Novel Curcumin Analogs with anticipated anticancer activity
-
- Fawzy, Iten M. (author)
- Future Univ, Fac Pharmaceut Sci & Pharmaceut Ind, Pharmaceut Chem Dept, Cairo 12311, Egypt.
-
- Youssef, Khairia M. (author)
- Future Univ, Fac Pharmaceut Sci & Pharmaceut Ind, Pharmaceut Chem Dept, Cairo 12311, Egypt.
-
- Ismail, Nasser S. M. (author)
- Ain Shams Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo, Egypt.
- show more...
- show less...
- Future Univ, Fac Pharmaceut Sci & Pharmaceut Ind, Pharmaceut Chem Dept, Cairo 12311, Egypt Ain Shams Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo, Egypt. (creator_code:org_t)
- ELSEVIER SCIENCE BV, 2015
- 2015
- English.
- In: FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES. - : ELSEVIER SCIENCE BV. - 2314-7245. ; 1:1, s. 22-31
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Context: Extensive research conducted within past years revealed that curcumin is a highly pleiotropic molecule that interacts with a diverse range of molecular targets and hence it possess anti-proliferative activities against tumor cells.The great similarities between curcumin analogs and chalcones inspired their testing against tubulin enzyme activity as recent research revealed that chalcones possess cytotoxic activity associated with tubulin inhibition and interference with microtubule formation, which is essential in mitosis and cell replication. Objective: Novel Curcumin analogs were designed, synthesized and tested for their antitumor activities. Also in silico and in vitro studies has been performed to predict the binding affinity of the target compounds and to test their ability to inhibit tubulin assembly and act as microtubule destabilizing agents. Methods: Six novel curcumin analogs were designed & synthesized with 3,5-dibenzylidenepiperidin-4-one core moiety. Results: Compounds showed interaction energy comparable to or within the range of podophyllotoxin itself when docked into the colchicine binding site of tubulin using the podophyllotoxin-tubulin complex (PDB 1SA1). Conclusion: Compounds showed moderate anticancer activity and moderate ability to destabilize microtubules and thus inhibiting tubulin polymerization, as a result; these compounds could be used for further future development to obtain more potent analogs. (C) 2015 Future University. Production and hosting by Elsevier B.V.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Curcumin analogs
- In silico molecular docking
- Anti proliferative activity
- Tubulin polymerization
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Fawzy, Iten M.
- Youssef, Khairia ...
- Ismail, Nasser S ...
- Gullbo, Joachim
- Abouzid, Khaled ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmacology and ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- FUTURE JOURNAL O ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
