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Intrathecal immunoglobulins and neurofilament light after autologous haematopoietic stem cell transplantation for multiple sclerosis
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- Larsson, Diane (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Åkerfeldt, Torbjörn (author)
- Uppsala universitet,Klinisk kemi
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi
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- (creator_code:org_t)
- 2019-07-26
- 2020
- English.
- In: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 26:11, s. 1351-1359
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND: Oligoclonal bands (OCB) are widely believed to be stable over time and rarely affected by disease-modifying treatment in MS. It is presently unknown how intrathecal immunoglobulin production and other cerebrospinal fluid (CSF) biomarkers are impacted by a highly efficacious procedure such as autologous haematopoietic stem cell transplantation (aHSCT).OBJECTIVE: To describe the evolution of intrathecal immunoglobulin and neurofilament light (NFL) over time in MS patients treated with aHSCT.METHODS: In this retrospective study, available data from previously made CSF investigations in 46 patients treated with aHSCT were analysed.RESULTS: After a median follow-up time of 745 days, immunoglobulin G (IgG) OCB remained detectable in 74% of patients, the proportion of patients with a pathological IgG index went down from 70% to 46%, and the proportion of patients with a pathological NFL went down from 72% to 24%. In patients with follow-up time >1500 days, IgG OCB were detectable in 50% of patients, 14% had a pathological IgG index and none a pathological NFL.CONCLUSIONS: Intrathecal immunoglobulin production and NFL were lower after treatment with aHSCT, decreased over time and were normalised in a significant portion of patients. This challenges the notion that OCB are unaffected by therapeutic intervention in MS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Biomarkers
- CSF
- autologous hematopoietic stem cell transplantation
- multiple sclerosis
- relapsing/remitting
Publication and Content Type
- ref (subject category)
- art (subject category)
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