The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

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Fältnamn	Indikatorer	Metadata
000		04653naa a2200505 4500
001		oai:DiVA.org:uu-433908
003		SwePub
008		210203s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:145569241
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4339082 URI
024	7	a https://doi.org/10.3389/fncel.2020.6013242 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1455692412 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Hariharan, Ashwiniu Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut
245	1 0	a The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes
264		c 2020-12-18
264	1	a LAUSANNE, SWITZERLAND :b Frontiers Media SA,c 2020
338		a electronic2 rdacarrier
520		a Brain pericytes reside on the abluminal surface of capillaries, and their processes cover similar to 90% of the length of the capillary bed. These cells were first described almost 150 years ago (Eberth, 1871; Rouget, 1873) and have been the subject of intense experimental scrutiny in recent years, but their physiological roles remain uncertain and little is known of the complement of signaling elements that they employ to carry out their functions. In this review, we synthesize functional data with single-cell RNAseq screens to explore the ion channel and G protein-coupled receptor (GPCR) toolkit of mesh and thin-strand pericytes of the brain, with the aim of providing a framework for deeper explorations of the molecular mechanisms that govern pericyte physiology. We argue that their complement of channels and receptors ideally positions capillary pericytes to play a central role in adapting blood flow to meet the challenge of satisfying neuronal energy requirements from deep within the capillary bed, by enabling dynamic regulation of their membrane potential to influence the electrical output of the cell. In particular, we outline how genetic and functional evidence suggest an important role for G(s)-coupled GPCRs and ATP-sensitive potassium (K-ATP) channels in this context. We put forth a predictive model for long-range hyperpolarizing electrical signaling from pericytes to upstream arterioles, and detail the TRP and Ca2+ channels and G(q), G(i/o), and G(12/13) signaling processes that counterbalance this. We underscore critical questions that need to be addressed to further advance our understanding of the signaling topology of capillary pericytes, and how this contributes to their physiological roles and their dysfunction in disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a pericytes
653		a ion channels
653		a GPCRs (G protein coupled receptors)
653		a neurovascular coupling (NVC)
653		a cerebral blood flow (CBF)
653		a K-ATP channels
653		a brain metabolism
700	1	a Weir, Nicku Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut
700	1	a Robertson, Colinu Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut
700	1	a He, Liqunu Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.4 aut0 (Swepub:uu)liqhe592
700	1	a Betsholtz, Christeru Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.;Karolinska Inst, Dept Med Huddinge MedH, Huddinge, Sweden.;Integrated Cardio Metab Ctr, Huddinge, Sweden.4 aut0 (Swepub:uu)chbet517
700	1	a Longden, Thomas A.u Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut
710	2	a Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.b Vaskulärbiologi4 org
773	0	t Frontiers in Cellular Neuroscienced LAUSANNE, SWITZERLAND : Frontiers Media SAg 14q 14x 1662-5102
856	4	u https://doi.org/10.3389/fncel.2020.601324y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1525446/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.frontiersin.org/articles/10.3389/fncel.2020.601324/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433908
856	4 8	u https://doi.org/10.3389/fncel.2020.601324
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145569241

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