id:"swepub:oai:DiVA.org:uu-437381"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03775naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-437381 | |
| 003 | SwePub | |
| 008 | 210309s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4373812 URI |
| 024 | 7 | a https://doi.org/10.1007/s12350-021-02550-92 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nordström, Jonnyu Uppsala universitet,Radiologi,Centrum för klinisk forskning, Gävleborg4 aut0 (Swepub:uu)jonno413 |
| 245 | 1 0 | a Influence of patient motion on quantitative accuracy in cardiac 15O-water positron emission tomography. |
| 264 | c 2021-03-02 | |
| 264 | 1 | b Springer Nature,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a BACKGROUND: Patient motion is a common problem during cardiac PET. The purpose of the present study was to investigate to what extent motions influence the quantitative accuracy of cardiac 15O-water PET/CT and to develop a method for automated motion detection.METHOD: Frequency and magnitude of motion was assessed visually using data from 50 clinical 15O-water PET/CT scans. Simulations of 4 types of motions with amplitude of 5 to 20 mm were performed based on data from 10 scans. An automated motion detection algorithm was evaluated on clinical and simulated motion data. MBF and PTF of all simulated scans were compared to the original scan used as reference.RESULTS: Patient motion was detected in 68% of clinical cases by visual inspection. All observed motions were small with amplitudes less than half the LV wall thickness. A clear pattern of motion influence was seen in the simulations with a decrease of myocardial blood flow (MBF) in the region of myocardium to where the motion was directed. The perfusable tissue fraction (PTF) trended in the opposite direction. Global absolute average deviation of MBF was 3.1% ± 1.8% and 7.3% ± 6.3% for motions with maximum amplitudes of 5 and 20 mm, respectively. Automated motion detection showed a sensitivity of 90% for simulated motions ≥ 10 mm but struggled with the smaller (≤ 5 mm) simulated (sensitivity 45%) and clinical motions (accuracy 48%).CONCLUSION: Patient motion can impair the quantitative accuracy of MBF. However, at typically occurring levels of patient motion, effects are similar to or only slightly larger than inter-observer variability, and downstream clinical effects are likely negligible. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a CAD | |
| 653 | a Myocardial blood flow | |
| 653 | a PET | |
| 653 | a image interpretation | |
| 700 | 1 | a Harms, Hendrik J4 aut |
| 700 | 1 | a Kero, Tanjau Uppsala universitet,Radiologi4 aut0 (Swepub:uu)tanke311 |
| 700 | 1 | a Sörensen, Jensu Uppsala universitet,Radiologi,Klinisk fysiologi4 aut0 (Swepub:uu)jenssore |
| 700 | 1 | a Lubberink, Marku Uppsala universitet,Radiologi,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)marklubb |
| 710 | 2 | a Uppsala universitetb Radiologi4 org |
| 773 | 0 | t Journal of Nuclear Cardiologyd : Springer Natureg 29:4, s. 1742-1752q 29:4<1742-1752x 1071-3581x 1532-6551 |
| 856 | 4 | u https://doi.org/10.1007/s12350-021-02550-9y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1536011/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s12350-021-02550-9.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437381 |
| 856 | 4 8 | u https://doi.org/10.1007/s12350-021-02550-9 |
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