Go with your gut: The human intestinal microbiota, international travel, Campylobacter and ESBL-producing Enterobacteriaceae

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:uu-438449" > Go with your gut :

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		06539nam a2200685 4500
001		oai:DiVA.org:uu-438449
003		SwePub
008		210325s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
020		a 9789151311715q print
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4384492 URI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a dok2 swepub-publicationtype
100	1	a Kampmann, Christian,d 1975-u Uppsala universitet,Klinisk mikrobiologi,Infektionskliniken, Skånes Universitetssjukhus, Lund4 aut0 (Swepub:uu)chrka744
245	1 0	a Go with your gut :b The human intestinal microbiota, international travel, Campylobacter and ESBL-producing Enterobacteriaceae
264	1	a Uppsala :b Acta Universitatis Upsaliensis,c 2021
300		a 91 s.
338		a electronic2 rdacarrier
490	0	a Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,x 1651-6206 ;v 1735
500		a Vid intresse av att närvara digitalt, vänligen kontakta: christian.kampmann@medsci.uu.se för att få en länk.
520		a Up to 100 million people travel annually from industrialized countries to resource-limited ones. Each traveller contains an internal ecosystem composed of tens of trillions of microbes, known as the intestinal microbiota, which has a large effect on health. The microbiota seems to be highly individual and mostly stable but can be significantly affected by several factors. Many international travellers are at high risk of getting infected by Campylobacter, the most common cause of bacterial enteritis worldwide. Campylobacter infection can cause a wide range of symptoms, with varying severity, for reasons largely unknown. Travel also radically increases the risk of colonization by antibiotic-resistant intestinal bacteria, notably Extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EPE). To date, there are no therapies available for EPE-decolonization. In this thesis, it was investigated whether the bacterial intestinal microbiota affected susceptibility to Campylobacter and if international travel as such had an impact on the microbiota. In a prospective, observational study, 67 healthy Swedes, travelling in groups to countries with a high risk of Campylobacter infection, were followed. The travellers answered questionnaires and delivered two faecal samples before and three samples after the trip. These samples were cultured for enteropathogens and analysed for the microbiota composition. Low diversity of microbiota seemed to increase the risk of Campylobacter jejuni infection, whereas a high relative abundance of Lachnospiraceae might decrease the risk (Paper I). Furthermore, the overall bacterial diversity did not seem to change in connection with travelling. However, the bacterial family Enterobacteriaceae (otherwise connected with inflammation, infection and antibiotic-resistance) was shown to be dramatically increased in abundance immediately after travel, and the family Christensenellaceae (otherwise connected with beneficial health conditions) simultaneously decreased (Paper II). Eight travellers, from two different destinations, were infected with closely related C. jejuni isolates (ST353CC). The bacterial analysis of genomic and phenotypic characteristics revealed that the C. jejuni isolates of the travellers returning from one of the destinations and with more severe symptoms actually showed less pathogenic potential, compared to the isolates of travellers from the other destination and with milder symptoms. However, the travellers with more severe symptoms had much higher relative abundances of Bacteroidetes in their intestinal microbiota and, in contrast to the other travellers, excluded meat from their diet. (Paper III) Finally, we investigated in a randomized, placebo-controlled clinical trial of 80 established intestinal carriers of EPE, whether the oral probiotic product Vivomixx® could eradicate EPE. Vivomixx® was not superior to placebo (Paper IV).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653		a travel
653		a travellers´diarrhea
653		a microbiota
653		a Campylobacter
653		a Campylobacter jejuni
653		a ST353CC
653		a colonization resistance
653		a enteritis
653		a infection
653		a Enterobacteriaceae
653		a Christensenellaceae
653		a Lachnospiraceae
653		a whole genome sequence
653		a vegetarian
653		a bacterial resistance
653		a ESBL
653		a Extended spectrum beta-lactamase
653		a probiotics
653		a intestinal decolonization
653		a eradication treatment
653		a Infektionssjukdomar
653		a Infectious Diseases
700	1	a Rautelin, Hilpi,c Professoru Uppsala universitet,Klinisk mikrobiologi4 ths0 (Swepub:uu)hilra999
700	1	a Dicksved, Johan,c Docentu Swedish University of Agricultural Sciences, Uppsala. Department of Animal Nutrition and Management4 ths
700	1	a Engstrand, Lars,c Professoru Karolinska Institute, Stockholm. Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology4 ths
700	1	a Tham, Johan,c Docentu Lund University. Clinical Microbiology and Clinical Infection Medicine, Department of Translational Medicine, Faculty of Medicine, Malmö4 ths
700	1	a Ursing, Johan,c Docentu Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute4 opn
710	2	a Uppsala universitetb Klinisk mikrobiologi4 org
856	4	u https://uu.diva-portal.org/smash/get/diva2:1539653/FULLTEXT01.pdfx primaryx Raw objecty fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1539653/PREVIEW01.jpgx Previewy preview image
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438449

Hitta via bibliotek

Go with your gut The human intestinal microbiota, international travel, Campylob... (Sök publikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Kampmann, Christ ...; Rautelin, Hilpi, ...; Dicksved, Johan, ...; Engstrand, Lars, ...; Tham, Johan, Doc ...; Ursing, Johan, D ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Klinisk laborato ...

Delar i serien: Digital Comprehe ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se