id:"swepub:oai:DiVA.org:uu-440804"
Search: id:"swepub:oai:DiVA.org:uu-440804" > Synthesis and Precl...
- 1 of 1
- Previous record
- Next record
- To hitlist
Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake
- Krasikova, Raisa (author)
-
- Kondrashov, Mikhail (author)
- Karolinska Institutet
- Avagliano, Camilla (author)
- show more...
- Petukhov, Mikhail (author)
- Vazquez-Romero, Ana (author)
- Revunov, Evgeny (author)
- Johnström, Peter (author)
- Tari, Lenke (author)
- Häggkvist, Jenny (author)
- show less...
- (creator_code:org_t)
- 2020-04-28
- 2020
- English.
- In: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 11:12, s. 1756-1761
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The positron emission tomography (PET) radioligand α-[11C]methyl-l-tryptophan ([11C]AMT) has been used to assess tryptophan metabolism in cancer, epilepsy, migraine, and autism. Despite its extensive application, the utility of this tracer is currently hampered by the short half-life of the radionuclide used for its labeling (11C, t1/2 = 20.4 min). We herein report the design, synthesis, radiolabeling, and initial in vivo evaluation of a fluorine-18 (18F, t 1/2 = 109.7 min) labeled analogue that is fluorinated in the 6-position of the aromatic ring ([18F]6-F-AMTr). In a head-to-head comparison between [18F]6-F-AMTr and [11C]AMT in mice using PET, peak brain radioactivity, regional brain distribution, and kinetic profiles were similar between the two tracers. [18F]6-F-AMTr was however not a substrate for IDO1 or TPH as determined in in vitro enzymatic assays. The brain uptake of the tracer is thus more likely related to LAT1 transport over the blood-brain barrier than metabolism along the serotonin or kynurenine pathways.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Brain
- Fluorine-18
- Kynurenine
- LAT1
- PET
- Tryptophan
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- ACS Chemical Neuroscience (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Krasikova, Raisa
- Kondrashov, Mikh ...
- Avagliano, Camil ...
- Petukhov, Mikhai ...
- Vazquez-Romero, ...
- Revunov, Evgeny
- show more...
- Johnström, Peter
- Tari, Lenke
- Tóth, Miklós
- Häggkvist, Jenny
- Erhardt, Sophie
- Cervenka, Simon
- Schou, Magnus
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Radiology Nuclea ...
- Articles in the publication
- ACS Chemical Neu ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
