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Inflammation-relate...
Inflammation-related plasma protein levels and association with adiposity measurements in young adults
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- Klevebro, Susanna (författare)
- Karolinska Institutet
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- Björkander, Sophia (författare)
- Karolinska Institutet
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- Ekström, Sandra (författare)
- Karolinska Institutet
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- Merid, Simon K. (författare)
- Karolinska Inst, Dept Clin Sci & Educ, Södersjukhuset, Sjukhusbacken 10, S-11883 Stockholm, Sweden
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- Gruzieva, Olena (författare)
- Karolinska Institutet
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- Mälarstig, Anders (författare)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Johansson, Åsa (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Kull, Inger (författare)
- Karolinska Institutet
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- Bergström, Anna (författare)
- Karolinska Institutet
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- Melén, Erik (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-05-31
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Obesity-related inflammation is associated with cardiovascular, metabolic, and pulmonary diseases. The aim of this study was to demonstrate associations between adiposity measurements and levels of inflammation-related plasma proteins in a population of young adults. Subjects from a population-based birth cohort with a mean age of 22.5 years were included in the study population (n=2074). Protein levels were analyzed using the Olink Proseek Multiplex Inflammation panel. Percentage body fat (%BF) and visceral fat rating (VFR) measurements were collected using Tanita MC 780 body composition monitor. Linear regression of standardized values was used to investigate associations. Potential effect modifications by sex and BMI category were assessed. Of 71 investigated proteins, 54 were significantly associated with all adiposity measurements [%BF, body mass index (BMI), VFR and waist circumference]. Among proteins associated with %BF, seven showed a larger or unique association in overweight/obese subjects and three showed a significant effect modification by sex. Fourteen proteins more strongly associated with VFR in females compared to males. Adipose-associated systemic inflammation was observed in this young adult population. Sex and adiposity localization influenced some of the associations. Our results highlight specific proteins as suitable biomarkers related to adiposity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Klevebro, Susann ...
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Björkander, Soph ...
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Ekström, Sandra
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Merid, Simon K.
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Gruzieva, Olena
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Mälarstig, Ander ...
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visa fler...
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Johansson, Åsa
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Kull, Inger
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Bergström, Anna
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Melén, Erik
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet