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Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in women with endometriosis : nationwide cohort study
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- Brunes, M. (author)
- Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden.
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- Altman, Daniel (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Stockholm Urogynaecol Clin, Stockholm, Sweden.
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- Pålsson, M. (author)
- Gothenburg Univ, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynaecol, Gothenburg, Sweden.
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- Karolinska Institutet Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden. (creator_code:org_t)
- 2020-09-06
- 2021
- English.
- In: British Journal of Obstetrics and Gynecology. - : John Wiley & Sons. - 1470-0328 .- 1471-0528. ; 128:5, s. 846-855
- Journal article (peer-reviewed)
Abstract
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- Objective: To evaluate how hysterectomy affects the prescription of analgesic, psychotropic and neuroactive drugs in women with endometriosis using population-based nationwide registers.Design: Nationwide cohort study.Setting: Swedish national registers, from 1 January 2009 to 31 December 2018.Population: Women with benign disease undergoing a total hysterectomy during the 4-year period of 2012-2015. Women with endometriosis (n = 1074) were identified and compared with women who did not have endometriosis (n = 10 890).Methods: Prospectively collected data from two population-based registers were linked: the Swedish National Quality Register of Gynaecological Surgery and the Swedish National Drug Register. Multivariate logistic regression was used as the main statistical method.Main outcome measures: Changes in drug prescription over time for 3 years prior to and 3 years after hysterectomy.Results: The frequency of prescription of analgesics was higher in women with endometriosis compared with women without endometriosis (OR 2.2, 95% CI 1.7-2.9). Among women with endometriosis, the prescription of analgesics (OR 1.0, 95% CI 0.8-1.2) did not decrease 3 years after hysterectomy compared with the 3 years prior to surgery. There was also a significantly higher rate of prescription of psychoactive (OR 1.6, 95% CI 1.4-2.0) and neuroactive drugs (OR 1.9, 95% CI 1.3-2.7) in the long term postoperatively.Conclusions: In women undergoing hysterectomy, endometriosis was associated with a higher prescription rate of analgesics. In the endometriosis group the prescription of analgesic, psychoactive and neuroactive drugs did not decrease when comparing prescription rates for the 3 years prior to and the 3 years after surgery. Tweetable abstract In women with endometriosis, the long-term prescription of analgesics did not decrease after hysterectomy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Endometriosis
- hysterectomy
- pain
- prescription
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Altman, Daniel
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- Söderberg, M. W.
- Ek, M.
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