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A novel podocyte pr...
A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane
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- Ishikawa, Takahiro (author)
- Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan
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- Takemoto, Minoru (author)
- Int Univ Hlth & Welf, Sch Med, Dept Diabet Metab & Endocrinol, 4-3 Kozunomori, Narita, Chiba 2868686, Japan
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- Akimoto, Yoshihiro (author)
- Kyorin Univ, Dept Anat, Sch Med, Tokyo, Japan
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- Takada-Watanabe, Aki (author)
- Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan
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- Yan, Kunimasa (author)
- Kyorin Univ, Dept Pediat, Sch Med, Tokyo, Japan
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- Sakamoto, Kenichi (author)
- Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan
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- Maezawa, Yoshiro (author)
- Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan
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- Suguro, Miyuki (author)
- Aichi Canc Ctr, Res Inst, Nagoya, Aichi, Japan
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- He, Liqun (author)
- Uppsala universitet,Vaskulärbiologi
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- Tryggvason, Karl (author)
- Duke NUS Grad Med Sch Singapore, Cardiovasc & Metab Disorders Program, Singapore, Singapore
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- Betsholtz, Christer (author)
- Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Dept Med Huddinge, Campus Flemingsberg, SE-14157 Huddinge, Sweden
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- Yokote, Koutaro (author)
- Chiba Univ, Dept Endocrinol Hematol & Gerontol, Grad Sch Med, Chiba 2608670, Japan
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(creator_code:org_t)
- 2021-02-23
- 2021
- English.
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In: Journal of Molecular Medicine. - : Springer Science and Business Media LLC. - 0946-2716 .- 1432-1440. ; 99:6, s. 859-876
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Not only in kidney glomerular physiological function but also glomerular pathology especially in diabetic condition, glomerular podocytes play pivotal roles. Therefore, it is important to increase our knowledge about the genes and proteins expressed in podocytes. Recently, we have identified a novel podocyte-expressed gene, R3h domain containing-like (R3hdml) and analyzed its function in vivo as well as in vitro. Transforming growth factor-β (TGF-β) signaling regulated the expression of R3hdml. And R3hdml inhibited p38 mitogen-activated protein kinase phosphorylation, which was induced by TGF-β, leading to the amelioration of podocyte apoptosis. Furthermore, a lack of R3hdml in mice significantly worsened glomerular function in streptozotocin (STZ)-induced diabetes, while overexpression of R3hdml ameliorated albuminuria in STZ-induced diabetes. Our results surmise that the functional analyses of R3hdml may lead to the development of novel therapeutic strategies for diabetic nephropathy in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Apoptosis
- Diabetic nephropathy
- Podocyte
- p38mapk
- TGF-beta
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ishikawa, Takahi ...
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Takemoto, Minoru
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Akimoto, Yoshihi ...
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Takada-Watanabe, ...
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Yan, Kunimasa
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Sakamoto, Kenich ...
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show more...
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Maezawa, Yoshiro
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Suguro, Miyuki
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He, Liqun
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Tryggvason, Karl
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Betsholtz, Chris ...
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Yokote, Koutaro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Journal of Molec ...
- By the university
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Uppsala University
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Karolinska Institutet