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PO-124 Childhood Le...
PO-124 Childhood Leukemia International Consortium (CLIC) Studies Report Diffrential Associations of Advanced Parental Age with Childhood Acute Lymphoblastic Leukemia
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- Petridou, E. (author)
- National and Kapodistrian University of Athens Medical School, Dept. of Hygiene- Epidemiology and Medical Statistics, Athens, Greece; 2Karolinska Institute, Clinical Epidemiology Unit- Department of Medicine, Stockholm, Sweden
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- Georgakis, M. (author)
- National and Kapodistrian University of Athens Medical School, Dept. of Hygiene- Epidemiology and Medical Statistics, Athens, Greece
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- Erdmann, F. (author)
- International Agency for Research on Cancer, Section of Environment and Radiation, Lyon, France; Danish Cancer Society Research Center, Childhood Cancer Survivorship Research Group- Unit of Survivorship, Copenhagen, Denmark
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- Ezzat, S. (author)
- National Liver Institute- Menoufia University, Department of Epidemiology and Preventive Medicine- NLI-SSI Collaborative Research Center, Caire, Egypt
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- Mora, A.M. (author)
- Universidad Nacional Heredia, Central American Institute for Studies on Toxic Substances IRET, Heredia, Costa Rica
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- Dessypris, N. (author)
- National and Kapodistrian University of Athens Medical School, Dept. of Hygiene- Epidemiology and Medical Statistics, Athens, Greece
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- Schüz, J. (author)
- International Agency for Research on Cancer, Section of Environment and Radiation, Lyon, France
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- Infante-Rivard, C. (author)
- McGill University, Department of Epidemiology- Biostatistics and Occupational Health Faculty of Medicine, Montreal- Québec, Canada
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- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- C.S.G. CLIC Studies Group, - (author)
- CLIC Studies Group, Athens, Greece
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National and Kapodistrian University of Athens Medical School, Dept of Hygiene- Epidemiology and Medical Statistics, Athens, Greece; 2Karolinska Institute, Clinical Epidemiology Unit- Department of Medicine, Stockholm, Sweden National and Kapodistrian University of Athens Medical School, Dept. of Hygiene- Epidemiology and Medical Statistics, Athens, Greece (creator_code:org_t)
- 2018-09-21
- 2018
- English.
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In: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 65:52, s. S150-S151
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background/Objectives:Advanced parental age has beenassociated with adverse health effects in the offspring includ-ing childhood (0-14 years) acute lymphoblastic leukemia(ALL), as reported in our meta-analysis of published stud-ies. Primary data from 16 studies participating in theChildhood Leukemia International Consortium provide aunique methodological opportunity to further explore thisassociation.Design/Methods:Data from 11 case-control (CC) studies(7919 cases; 12942 interviewed controls) and five nested case-control (NCC) studies (8801 cases; 29690 controls recordlinked via population-based registries) with enrollment peri-ods ranging from 1968 to 2015 were used. Adjusted oddsratios (OR) were derived from each study using five-yearpaternal and maternal age increments and introduded in twometa-analyses by CC or NCC study design.Results:Advancement of paternal age was associated withstatistically significant higher risk for ALL in the off-spring (ORCC:1.05; ORNCC:1.04) and advanced mater-nal age only in the NCC (ORNCC:1.05). By contrast, theresults were heterogeneous in CC studies (ORCC:0.99, 95%CI:0.91-1.07, heterogeneityI2=58%,p=0.002). The positive association between parental age and risk of ALL was moreevident in the age group among 1-5 years and remainedunchanged after mutual adjustment for the collinear effect ofthe paternal and maternal age variables. We further performedanalyses of the relatively small numbers of discordant pater-nal and maternal age pairs to explore the collinear effect ofparental age but the results were not fully enlightening.Conclusions:The results of this larger ever dataset of primarydata allowing for separate analysis by study design and bettercontrol of selection bias in CC studies strengthen the evidencethat advanced parental age is associated with increased child-hood ALL risk. The observational study design and ollinear-ity of maternal with paternal age complicate causal interpre-tation. Employing datasets with cytogenetic information mayfurther elucidate involvement of each parental component andclarify underlying mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- art (subject category)
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