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Sökning: id:"swepub:oai:DiVA.org:uu-462872" > Functional improvem...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005781naa a2200541 4500
001oai:DiVA.org:uu-462872
003SwePub
008220103s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:148434009
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4628722 URI
0247 a https://doi.org/10.1016/j.exger.2021.1116312 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1484340092 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Skoglund, Elisabethu Uppsala universitet,Klinisk nutrition och metabolism,Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Alfred Nobles Allé 8B, 141 52 Huddinge, Sweden & Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden4 aut0 (Swepub:uu)elibe194
2451 0a Functional improvements to 6 months of physical activity are not related to changes in size or density of multiple lower-extremity muscles in mobility-limited older individuals
264 1b Elsevier BV,c 2022
338 a electronic2 rdacarrier
520 a Older adults are encouraged to engage in multicomponent physical activity, which includes aerobic and muscle-strengthening activities. The current work is an extension of the Vitality, Independence, and Vigor in the Elderly 2 (VIVE2) study - a 6-month multicenter, randomized, placebo-controlled trial of physical activity and nutritional supplementation in community dwelling 70-year-old seniors. Here, we examined whether the magnitude of changes in muscle size and quality differed between major lower-extremity muscle groups and related these changes to functional outcomes. We also examined whether daily vitamin-D-enriched protein supplementation could augment the response to structured physical activity. Forty-nine men and women (77 ± 5 yrs) performed brisk walking, muscle-strengthening exercises for the lower limbs, and balance training 3 times weekly for 6 months. Participants were randomized to daily intake of a nutritional supplement (20 g whey protein + 800 IU vitamin D), or a placebo. Muscle cross-sectional area (CSA) and radiological attenuation (RA) were assessed in 8 different muscle groups using single-slice CT scans of the hip, thigh, and calf at baseline and after the intervention. Walking speed and performance in the Short Physical Performance Battery (SPPB) were also measured. For both CSA and RA, there were muscle group × time interactions (P < 0.01). Significant increases in CSA were observed in 2 of the 8 muscles studied, namely the knee extensors (1.9%) and the hip adductors (2.8%). For RA, increases were observed in 4 of 8 muscle groups, namely the hip flexors (1.1 HU), hip adductors (0.9 HU), knee extensors (1.2 HU), and ankle dorsiflexors (0.8 HU). No additive effect of nutritional supplementation was observed. While walking speed (13%) and SPPB performance (38%) improved markedly, multivariate analysis showed that these changes were not associated with the changes in muscle CSA and RA after the intervention. We conclude that this type of multicomponent physical activity program results in significant improvements in physical function despite relatively small changes in muscle size and quality of some, but not all, of the measured lower extremity muscles involved in locomotion.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
653 a Computed tomography
653 a Cross-sectional area
653 a Hounsfield units
653 a Sarcopenia
653 a Skeletal muscle
653 a Vitamin D
7001 a Lundberg, Tommy Ru Karolinska Institutet4 aut
7001 a Rullman, Ericu Karolinska Institutet4 aut
7001 a Fielding, Roger Au Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA4 aut
7001 a Kirn, Dylan Ru Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA4 aut
7001 a Englund, Davis Au Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA4 aut
7001 a von Berens, Asau Uppsala universitet,Klinisk nutrition och metabolism,Stockholm Gerontology Research Center, Sveavägen 155, 113 46 Stockholm, Sweden4 aut0 (Swepub:uu)asavo144
7001 a Koochek, Afsanehu Uppsala universitet,Institutionen för kostvetenskap4 aut0 (Swepub:uu)afsko376
7001 a Cederholm, Tommyu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)tomce419
7001 a Berg, Hans Eu Karolinska Institutet4 aut
7001 a Gustafsson, Thomasu Karolinska Institutet4 aut
7102 a Uppsala universitetb Klinisk nutrition och metabolism4 org
7730 t Experimental Gerontologyd : Elsevier BVg 157q 157x 0531-5565x 1873-6815
8564 u https://doi.org/10.1016/j.exger.2021.111631y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1624318/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.exger.2021.111631
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462872
8564 8u https://doi.org/10.1016/j.exger.2021.111631
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148434009

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