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Sökning: id:"swepub:oai:DiVA.org:uu-470157" > (2022) > Eosinophilic airway...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006260naa a2200661 4500
001oai:DiVA.org:uu-470157
003SwePub
008220321s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:235251534
009oai:gup.ub.gu.se/323818
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4701572 URI
0247 a https://doi.org/10.1080/20018525.2022.20407072 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2352515342 URI
0247 a https://gup.ub.gu.se/publication/3238182 URI
040 a (SwePub)uud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
2451 0a Eosinophilic airway diseases :b basic science, clinical manifestations and future challenges
264 c 2022-03-02
264 1b Informa UK Limited,c 2022
338 a electronic2 rdacarrier
520 a Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. Eosinophil development, differentiation, activation, survival and recruitment are closely regulated by a number of type 2 cytokines, including interleukin (IL)-5, the key driver of eosinophilopoiesis. Evidence shows that type 2 inflammation, driven mainly by interleukin (IL)-4, IL-5 and IL-13, plays an important role in the pathophysiology of eosinophilic airway diseases, including asthma, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. Several biologic therapies have been developed to suppress type 2 inflammation, namely mepolizumab, reslizumab, benralizumab, dupilumab, omalizumab and tezepelumab. While these therapies have been associated with clinical benefits in a range of eosinophilic diseases, their development has highlighted several challenges and directions for future research. These include the need for further information on disease progression and identification of treatable traits, including clinical characteristics or biomarkers that will improve the prediction of treatment response. The Nordic countries have a long tradition of collaboration using patient registries and Nordic asthma registries provide unique opportunities to address these research questions. One example of such a registry is the NORdic Dataset for aSThmA Research (NORDSTAR), a longitudinal population-based dataset containing all 3.3 million individuals with asthma from four Nordic countries (Denmark, Finland, Norway and Sweden). Large-scale, real-world registry data such as those from Nordic countries may provide important information regarding the progression of eosinophilic asthma, in addition to clinical characteristics or biomarkers that could allow targeted treatment and ensure optimal patient outcomes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Eosinophil
653 a asthma
653 a severe asthma
653 a eosinophilic granulomatosis with polyangiitis
653 a chronic rhinosinusitis with nasal polyps
653 a hypereosinophilic syndrome
653 a registry
653 a real-world
653 a Nordic
653 a NORDSTAR
7001 a Bjermer, Leifu Skane Univ Hosp, Dept Resp Med & Allergol, Lund, Sweden.4 aut
7001 a Lehtimaki, Lauriu Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.4 aut
7001 a Kankaanranta, Hannu,d 1967u Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xkankh
7001 a Karjalainen, Jussiu Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.4 aut
7001 a Altraja, Alanu Tartu Univ Hosp, Univ Tartu & Lung Clin, Dept Pulmonol, Tartu, Estonia.4 aut
7001 a Yasinska, Valentynau Karolinska Institutet4 aut
7001 a Aarli, Berntu Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Thorac Med, Bergen, Norway.4 aut
7001 a Rådinger, Madeleine,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Krefting Research Centre,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xradim
7001 a Hellgren, Johan,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar,Institute of Clinical Sciences, Department of Otorhinolaryngology4 aut0 (Swepub:gu)xhellj
7001 a Lofdahl, Magnusu GSK, Resp Med Affairs, Solna, Sweden.4 aut
7001 a Howarth, Peter H.u GSK, Resp Med Franch, Brentford, Middlesex, England.4 aut
7001 a Porsbjerg, Celesteu Bispebjerg Hosp, Dept Resp Med, Copenhagen, Denmark.;Univ Copenhagen, Copenhagen, Denmark.4 aut
7102 a Uppsala universitetb Lung- allergi- och sömnforskning4 org
7730 t European Clinical Respiratory Journald : Informa UK Limitedg 9:1q 9:1x 2001-8525
8564 u https://doi.org/10.1080/20018525.2022.2040707y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1645978/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.tandfonline.com/doi/pdf/10.1080/20018525.2022.2040707?needAccess=true
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470157
8564 8u https://doi.org/10.1080/20018525.2022.2040707
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:235251534
8564 8u https://gup.ub.gu.se/publication/323818

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