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Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke : AFFINITY Study Findings

Chye, Alexander (author)
Hackett, Maree L (author)
Hankey, Graeme J (author)
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Lundström, Erik, 1964- (author)
Uppsala universitet,Neurologi
Almeida, Osvaldo P (author)
Gommans, John (author)
Dennis, Martin (author)
Jan, Stephen (author)
Mead, Gillian E (author)
Ford, Andrew H (author)
Beer, Christopher Etherton (author)
Flicker, Leon (author)
Delcourt, Candice (author)
Billot, Laurent (author)
Anderson, Craig S (author)
Stibrant Sunnerhagen, Katharina (author)
Yi, Qilong (author)
Bompoint, Severine (author)
Nguyen, Thang Huy (author)
Lung, Thomas (author)
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 (creator_code:org_t)
Ovid Technologies (Wolters Kluwer Health), 2022
2022
English.
In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 11:16
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https://uu.diva-port... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trialMethods and Results: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model.Conclusions: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value. Registration URL: http://www.anzctr.org.au; Unique identifier: ACTRN12611000774921.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

cerebrovascular disease
functional outcomes
modified Rankin Scale
partial proportional odds
repeated measures
stroke

Publication and Content Type

ref (subject category)
art (subject category)

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